View in EDS

Cannabinoid CB2 receptor drives trastuzumab resistance and predicts durable anti-HER2 response.

Saved in:
Bibliographic Details
Title: Cannabinoid CB2 receptor drives trastuzumab resistance and predicts durable anti-HER2 response.
Authors: Seijo-Vila M; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain., Balsinde SA; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain., Blasco-Benito S; Hospital del Mar Research Institute (IMIM), Barcelona, Spain., Tundidor I; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain., Rubert-Hernández M; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain., Montero-Calle A; Chronic Disease Programme (UFIEC), Instituto de Salud Carlos III, Madrid, Spain., Barderas R; Chronic Disease Programme (UFIEC), Instituto de Salud Carlos III, Madrid, Spain.; CIBER Frailty and Healthy Aging (CIBERFES), Madrid, Spain., Kilpatrick LE; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands, Nottingham, UK.; Division of Biomolecular Science and Medicinal Chemistry, School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Platt S; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands, Nottingham, UK.; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK., Karsai N; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands, Nottingham, UK.; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK., Philps I; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands, Nottingham, UK.; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK., Antón OM; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain., Gómez-Domínguez D; Gene Therapy Unit, Instituto de Investigación de Enfermedades Raras y Departamento de Desarrollo de Medicamentos y Terapias Avanzadas, Instituto de Salud Carlos III, Madrid, Spain., Pérez de Castro I; Gene Therapy Unit, Instituto de Investigación de Enfermedades Raras y Departamento de Desarrollo de Medicamentos y Terapias Avanzadas, Instituto de Salud Carlos III, Madrid, Spain., González-Lois C; Department of Pathology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain., García-Fresnadillo D; Department of Pathology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain., Silvestre-Egea G; Department of Pathology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain., Sánchez-López AJ; Neuroimmunology Unit, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain.; Biobank, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain., Ramírez-Medina E; Department of Gynecology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain., Rivas Prieto MC; Department of Gynecology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain., Almoguera Pérez-Cejuela B; Department of Gynecology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.; Department of Gynecology, HM Montepríncipe University Hospital, Madrid, Spain., Manso L; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.; Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain., Zazo S; Pathology Department, IIS-Hospital Universitario Fundación Jiménez Díaz-CIBERONC, Madrid, Spain., López-Ejeda N; Department of Biodiversity, Ecology and Evolution, Faculty of Biological Sciences, Nutritional Epidemiology (EPINUT) Research Group, Complutense University of Madrid, Madrid, Spain., Palomino-Duque F; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain., Turienzo-Durán M; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain., Martínez-Illescas NG; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain., Salazar-Roa M; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain., Castillo-Lluva S; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain., Hill SJ; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands, Nottingham, UK.; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK., Guzmán M; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Instituto Universitario de Investigación en Neuroquímica (IUIN), and Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Pérez-Gómez E; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain. eduperez@ucm.es.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain. eduperez@ucm.es., Sánchez C; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain. macsanch@ucm.es.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain. macsanch@ucm.es.
Source: Oncogene [Oncogene] 2026 Jul; Vol. 45 (25), pp. 2436-2451. Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42115409
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Cannabinoid CB<subscript>2</subscript> receptor drives trastuzumab resistance and predicts durable anti-HER2 response.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Seijo-Vila+M%22">Seijo-Vila M</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Balsinde+SA%22">Balsinde SA</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Blasco-Benito+S%22">Blasco-Benito S</searchLink>; Hospital del Mar Research Institute (IMIM), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Tundidor+I%22">Tundidor I</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rubert-Hernández+M%22">Rubert-Hernández M</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Montero-Calle+A%22">Montero-Calle A</searchLink>; Chronic Disease Programme (UFIEC), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Barderas+R%22">Barderas R</searchLink>; Chronic Disease Programme (UFIEC), Instituto de Salud Carlos III, Madrid, Spain.; CIBER Frailty and Healthy Aging (CIBERFES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Kilpatrick+LE%22">Kilpatrick LE</searchLink>; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands, Nottingham, UK.; Division of Biomolecular Science and Medicinal Chemistry, School of Pharmacy, Biodiscovery Institute, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Platt+S%22">Platt S</searchLink>; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands, Nottingham, UK.; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Karsai+N%22">Karsai N</searchLink>; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands, Nottingham, UK.; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Philps+I%22">Philps I</searchLink>; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands, Nottingham, UK.; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Antón+OM%22">Antón OM</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gómez-Domínguez+D%22">Gómez-Domínguez D</searchLink>; Gene Therapy Unit, Instituto de Investigación de Enfermedades Raras y Departamento de Desarrollo de Medicamentos y Terapias Avanzadas, Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez+de+Castro+I%22">Pérez de Castro I</searchLink>; Gene Therapy Unit, Instituto de Investigación de Enfermedades Raras y Departamento de Desarrollo de Medicamentos y Terapias Avanzadas, Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22González-Lois+C%22">González-Lois C</searchLink>; Department of Pathology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22García-Fresnadillo+D%22">García-Fresnadillo D</searchLink>; Department of Pathology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Silvestre-Egea+G%22">Silvestre-Egea G</searchLink>; Department of Pathology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez-López+AJ%22">Sánchez-López AJ</searchLink>; Neuroimmunology Unit, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain.; Biobank, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ramírez-Medina+E%22">Ramírez-Medina E</searchLink>; Department of Gynecology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rivas+Prieto+MC%22">Rivas Prieto MC</searchLink>; Department of Gynecology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Almoguera+Pérez-Cejuela+B%22">Almoguera Pérez-Cejuela B</searchLink>; Department of Gynecology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.; Department of Gynecology, HM Montepríncipe University Hospital, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Manso+L%22">Manso L</searchLink>; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.; Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Zazo+S%22">Zazo S</searchLink>; Pathology Department, IIS-Hospital Universitario Fundación Jiménez Díaz-CIBERONC, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22López-Ejeda+N%22">López-Ejeda N</searchLink>; Department of Biodiversity, Ecology and Evolution, Faculty of Biological Sciences, Nutritional Epidemiology (EPINUT) Research Group, Complutense University of Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Palomino-Duque+F%22">Palomino-Duque F</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Turienzo-Durán+M%22">Turienzo-Durán M</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-Illescas+NG%22">Martínez-Illescas NG</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Salazar-Roa+M%22">Salazar-Roa M</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Castillo-Lluva+S%22">Castillo-Lluva S</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Hill+SJ%22">Hill SJ</searchLink>; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands, Nottingham, UK.; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Guzmán+M%22">Guzmán M</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Instituto Universitario de Investigación en Neuroquímica (IUIN), and Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez-Gómez+E%22">Pérez-Gómez E</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain. eduperez@ucm.es.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain. eduperez@ucm.es.<br /><searchLink fieldCode="AU" term="%22Sánchez+C%22">Sánchez C</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain. macsanch@ucm.es.; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain. macsanch@ucm.es.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%228711562%22">Oncogene</searchLink> [Oncogene] 2026 Jul; Vol. 45 (25), pp. 2436-2451. <i>Date of Electronic Publication: </i>2026 May 11.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8711562 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5594 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209509232%22">09509232 </searchLink><i>NLM ISO Abbreviation: </i>Oncogene <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42115409
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41388-026-03814-9
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2436
    Titles:
      – TitleFull: Cannabinoid CB2 receptor drives trastuzumab resistance and predicts durable anti-HER2 response.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Seijo-Vila M
      – PersonEntity:
          Name:
            NameFull: Balsinde SA
      – PersonEntity:
          Name:
            NameFull: Blasco-Benito S
      – PersonEntity:
          Name:
            NameFull: Tundidor I
      – PersonEntity:
          Name:
            NameFull: Rubert-Hernández M
      – PersonEntity:
          Name:
            NameFull: Montero-Calle A
      – PersonEntity:
          Name:
            NameFull: Barderas R
      – PersonEntity:
          Name:
            NameFull: Kilpatrick LE
      – PersonEntity:
          Name:
            NameFull: Platt S
      – PersonEntity:
          Name:
            NameFull: Karsai N
      – PersonEntity:
          Name:
            NameFull: Philps I
      – PersonEntity:
          Name:
            NameFull: Antón OM
      – PersonEntity:
          Name:
            NameFull: Gómez-Domínguez D
      – PersonEntity:
          Name:
            NameFull: Pérez de Castro I
      – PersonEntity:
          Name:
            NameFull: González-Lois C
      – PersonEntity:
          Name:
            NameFull: García-Fresnadillo D
      – PersonEntity:
          Name:
            NameFull: Silvestre-Egea G
      – PersonEntity:
          Name:
            NameFull: Sánchez-López AJ
      – PersonEntity:
          Name:
            NameFull: Ramírez-Medina E
      – PersonEntity:
          Name:
            NameFull: Rivas Prieto MC
      – PersonEntity:
          Name:
            NameFull: Almoguera Pérez-Cejuela B
      – PersonEntity:
          Name:
            NameFull: Manso L
      – PersonEntity:
          Name:
            NameFull: Zazo S
      – PersonEntity:
          Name:
            NameFull: López-Ejeda N
      – PersonEntity:
          Name:
            NameFull: Palomino-Duque F
      – PersonEntity:
          Name:
            NameFull: Turienzo-Durán M
      – PersonEntity:
          Name:
            NameFull: Martínez-Illescas NG
      – PersonEntity:
          Name:
            NameFull: Salazar-Roa M
      – PersonEntity:
          Name:
            NameFull: Castillo-Lluva S
      – PersonEntity:
          Name:
            NameFull: Hill SJ
      – PersonEntity:
          Name:
            NameFull: Guzmán M
      – PersonEntity:
          Name:
            NameFull: Pérez-Gómez E
      – PersonEntity:
          Name:
            NameFull: Sánchez C
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: 2026 Jul
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1476-5594
          Numbering:
            – Type: volume
              Value: 45
            – Type: issue
              Value: 25
          Titles:
            – TitleFull: Oncogene
              Type: main
ResultId 1