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Mechanical force-induced tissue remodelling in a clinically relevant microphysiological model of asthmatic human lungs.

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Title: Mechanical force-induced tissue remodelling in a clinically relevant microphysiological model of asthmatic human lungs.
Authors: Paek J; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Department of Electrical and Computer Engineering, Binghamton University, Binghamton, NY, USA., Teegala LR; Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA., Alisafaei F; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA.; NSF Science and Technology Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Mechanical and Industrial Engineering, New Jersey Institute of Technology, Newark, NJ, USA., Alim A; Department of Electrical and Computer Engineering, Binghamton University, Binghamton, NY, USA., Song JW; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Park SE; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Chang J; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Liu H; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Kim BJ; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ryeom S; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shenoy V; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA.; NSF Science and Technology Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA., Clair GC; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Thodeti C; Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA., Paruchuri SM; Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA., Huh DD; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. huhd@seas.upenn.edu.; NSF Science and Technology Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA. huhd@seas.upenn.edu.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. huhd@seas.upenn.edu.
Source: Nature biomedical engineering [Nat Biomed Eng] 2026 May 11. Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Paek+J%22">Paek J</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Department of Electrical and Computer Engineering, Binghamton University, Binghamton, NY, USA.<br /><searchLink fieldCode="AU" term="%22Teegala+LR%22">Teegala LR</searchLink>; Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.<br /><searchLink fieldCode="AU" term="%22Alisafaei+F%22">Alisafaei F</searchLink>; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA.; NSF Science and Technology Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA.; Department of Mechanical and Industrial Engineering, New Jersey Institute of Technology, Newark, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Alim+A%22">Alim A</searchLink>; Department of Electrical and Computer Engineering, Binghamton University, Binghamton, NY, USA.<br /><searchLink fieldCode="AU" term="%22Song+JW%22">Song JW</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Park+SE%22">Park SE</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+J%22">Chang J</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+BJ%22">Kim BJ</searchLink>; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ryeom+S%22">Ryeom S</searchLink>; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Shenoy+V%22">Shenoy V</searchLink>; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA.; NSF Science and Technology Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Clair+GC%22">Clair GC</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Thodeti+C%22">Thodeti C</searchLink>; Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.<br /><searchLink fieldCode="AU" term="%22Paruchuri+SM%22">Paruchuri SM</searchLink>; Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.<br /><searchLink fieldCode="AU" term="%22Huh+DD%22">Huh DD</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. huhd@seas.upenn.edu.; NSF Science and Technology Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA. huhd@seas.upenn.edu.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. huhd@seas.upenn.edu.
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