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Decreased PP2A expression and activity represent a therapeutic target for plexiform neurofibroma.

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Title: Decreased PP2A expression and activity represent a therapeutic target for plexiform neurofibroma.
Authors: Yue M; Xuzhou Medical University, Xuzhou, China.; Affiliated Stomatological Hospital of Xuzhou Medical University, Jiangsu Province, 221004, Xuzhou, China., Wang Y; Xuzhou Medical University, Xuzhou, China., Gu J; Xuzhou Medical University, Xuzhou, China., Zhang C; Xuzhou Medical University, Xuzhou, China.; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China., Chen Y; Xuzhou Medical University, Xuzhou, China., Gao A; Xuzhou Medical University, Xuzhou, China., Choi K; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Wu Z; Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China., Wang Z; Neurofibromatosis Type 1 Center and Laboratory for Neurofibromatosis Type 1 Research, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China., Pundavela J; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Ratner N; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Nancy.Ratner@cchmc.org., Yu Y; Xuzhou Medical University, Xuzhou, China. ynyu@xzhmu.edu.cn.; Affiliated Stomatological Hospital of Xuzhou Medical University, Jiangsu Province, 221004, Xuzhou, China. ynyu@xzhmu.edu.cn.; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Xuzhou, 221004, Jiangsu Province, China. ynyu@xzhmu.edu.cn.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 May 11; Vol. 14 (1). Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Decreased PP2A expression and activity represent a therapeutic target for plexiform neurofibroma.
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  Data: <searchLink fieldCode="AU" term="%22Yue+M%22">Yue M</searchLink>; Xuzhou Medical University, Xuzhou, China.; Affiliated Stomatological Hospital of Xuzhou Medical University, Jiangsu Province, 221004, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Xuzhou Medical University, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Gu+J%22">Gu J</searchLink>; Xuzhou Medical University, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Xuzhou Medical University, Xuzhou, China.; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Xuzhou Medical University, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Gao+A%22">Gao A</searchLink>; Xuzhou Medical University, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Choi+K%22">Choi K</searchLink>; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Neurofibromatosis Type 1 Center and Laboratory for Neurofibromatosis Type 1 Research, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.<br /><searchLink fieldCode="AU" term="%22Pundavela+J%22">Pundavela J</searchLink>; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Ratner+N%22">Ratner N</searchLink>; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Nancy.Ratner@cchmc.org.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Xuzhou Medical University, Xuzhou, China. ynyu@xzhmu.edu.cn.; Affiliated Stomatological Hospital of Xuzhou Medical University, Jiangsu Province, 221004, Xuzhou, China. ynyu@xzhmu.edu.cn.; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Xuzhou, 221004, Jiangsu Province, China. ynyu@xzhmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101610673%22">Acta neuropathologica communications</searchLink> [Acta Neuropathol Commun] 2026 May 11; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 May 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101610673 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-5960 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220515960%22">20515960 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol Commun <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s40478-026-02315-w
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              Text: 2026 May 11
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