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How variants of uncertain significance affect clinical decisions: A systematic review.

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Title: How variants of uncertain significance affect clinical decisions: A systematic review.
Authors: Ayappa S; Johns Hopkins School of Medicine, Baltimore, MD., Joffe S; The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Medical Ethics and Health Policy at the University of Pennsylvania., Laberge AM; CHU Saint-Justine, Montreal, QC, Canada., Nye RT; The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA., Hess M; The Children's Hospital of Philadelphia, Philadelphia, PA., Callahan KP; The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Medical Ethics and Health Policy at the University of Pennsylvania. Electronic address: callahankp@chop.edu.
Source: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2026 Jul; Vol. 28 (7), pp. 102593. Date of Electronic Publication: 2026 May 12.
Publication Type: Systematic Review; Journal Article; Review
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 9815831 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0366 (Electronic) Linking ISSN: 10983600 NLM ISO Abbreviation: Genet Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: <searchLink fieldCode="AU" term="%22Ayappa+S%22">Ayappa S</searchLink>; Johns Hopkins School of Medicine, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Joffe+S%22">Joffe S</searchLink>; The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Medical Ethics and Health Policy at the University of Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Laberge+AM%22">Laberge AM</searchLink>; CHU Saint-Justine, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Nye+RT%22">Nye RT</searchLink>; The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Hess+M%22">Hess M</searchLink>; The Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Callahan+KP%22">Callahan KP</searchLink>; The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Medical Ethics and Health Policy at the University of Pennsylvania. Electronic address: callahankp@chop.edu.
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  Data: <searchLink fieldCode="JN" term="%229815831%22">Genetics in medicine : official journal of the American College of Medical Genetics</searchLink> [Genet Med] 2026 Jul; Vol. 28 (7), pp. 102593. <i>Date of Electronic Publication: </i>2026 May 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9815831 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1530-0366 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210983600%22">10983600 </searchLink><i>NLM ISO Abbreviation: </i>Genet Med <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.gim.2026.102593
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      – Code: eng
        Text: English
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              Text: 2026 Jul
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