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Dietary supplementation with ursolic acid preserves skeletal muscle mass and strength in mouse models of cancer cachexia.

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Title: Dietary supplementation with ursolic acid preserves skeletal muscle mass and strength in mouse models of cancer cachexia.
Authors: Ducharme JB; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States., Ebert SM; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States.; Emmyon, Inc., Rochester, Minnesota, United States., Cameron ME; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States.; Department of Surgery, University of Florida Health Science Center, Gainesville, Florida, United States., Schonk MM; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States., Callaway CS; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States., D'Lugos AC; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States., Talley JJ; Emmyon, Inc., Rochester, Minnesota, United States., Judge SM; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States.; Myology Institute, University of Florida, Gainesville, Florida, United States.; Health Cancer Institute, University of Florida, Gainesville, Florida, United States., Adams CM; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States.; Emmyon, Inc., Rochester, Minnesota, United States., Judge AR; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States.; Emmyon, Inc., Rochester, Minnesota, United States.; Myology Institute, University of Florida, Gainesville, Florida, United States.; Health Cancer Institute, University of Florida, Gainesville, Florida, United States.
Source: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2026 Jun 01; Vol. 330 (6), pp. C1800-C1811. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dietary supplementation with ursolic acid preserves skeletal muscle mass and strength in mouse models of cancer cachexia.
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  Data: <searchLink fieldCode="AU" term="%22Ducharme+JB%22">Ducharme JB</searchLink>; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Ebert+SM%22">Ebert SM</searchLink>; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States.; Emmyon, Inc., Rochester, Minnesota, United States.<br /><searchLink fieldCode="AU" term="%22Cameron+ME%22">Cameron ME</searchLink>; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States.; Department of Surgery, University of Florida Health Science Center, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Schonk+MM%22">Schonk MM</searchLink>; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Callaway+CS%22">Callaway CS</searchLink>; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22D'Lugos+AC%22">D'Lugos AC</searchLink>; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Talley+JJ%22">Talley JJ</searchLink>; Emmyon, Inc., Rochester, Minnesota, United States.<br /><searchLink fieldCode="AU" term="%22Judge+SM%22">Judge SM</searchLink>; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States.; Myology Institute, University of Florida, Gainesville, Florida, United States.; Health Cancer Institute, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Adams+CM%22">Adams CM</searchLink>; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States.; Emmyon, Inc., Rochester, Minnesota, United States.<br /><searchLink fieldCode="AU" term="%22Judge+AR%22">Judge AR</searchLink>; Department of Physical Therapy, University of Florida, Gainesville, Florida, United States.; Emmyon, Inc., Rochester, Minnesota, United States.; Myology Institute, University of Florida, Gainesville, Florida, United States.; Health Cancer Institute, University of Florida, Gainesville, Florida, United States.
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  Data: <searchLink fieldCode="JN" term="%22100901225%22">American journal of physiology. Cell physiology</searchLink> [Am J Physiol Cell Physiol] 2026 Jun 01; Vol. 330 (6), pp. C1800-C1811. <i>Date of Electronic Publication: </i>2026 May 12.
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        Value: 10.1152/ajpcell.00159.2026
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              Text: 2026 Jun 01
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