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Multiplex immunofluorescence microscopy assays for pharmacodynamic assessment of MET tyrosine kinase activation in the plasma membrane and nucleus.

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Title: Multiplex immunofluorescence microscopy assays for pharmacodynamic assessment of MET tyrosine kinase activation in the plasma membrane and nucleus.
Authors: Navas T; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America., Srivastava AK; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America., Lawrence SM; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America., Hollingshead MG; Biological Testing Branch, Developmental Therapeutics Program, National Cancer Institute at Frederick, Frederick, Maryland, United States of America., Alcoser SY; Biological Testing Branch, Developmental Therapeutics Program, National Cancer Institute at Frederick, Frederick, Maryland, United States of America., Miller SB; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, United States of America., Kinders RJ; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America., Bottaro DP; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America., Linehan WM; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America., Kummar S; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, United States of America., Doroshow JH; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, United States of America.; Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America., Parchment RE; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.
Source: PloS one [PLoS One] 2026 May 12; Vol. 21 (5), pp. e0349090. Date of Electronic Publication: 2026 May 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multiplex immunofluorescence microscopy assays for pharmacodynamic assessment of MET tyrosine kinase activation in the plasma membrane and nucleus.
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  Data: <searchLink fieldCode="AU" term="%22Navas+T%22">Navas T</searchLink>; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Srivastava+AK%22">Srivastava AK</searchLink>; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Lawrence+SM%22">Lawrence SM</searchLink>; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Hollingshead+MG%22">Hollingshead MG</searchLink>; Biological Testing Branch, Developmental Therapeutics Program, National Cancer Institute at Frederick, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Alcoser+SY%22">Alcoser SY</searchLink>; Biological Testing Branch, Developmental Therapeutics Program, National Cancer Institute at Frederick, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Miller+SB%22">Miller SB</searchLink>; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Kinders+RJ%22">Kinders RJ</searchLink>; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Bottaro+DP%22">Bottaro DP</searchLink>; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Linehan+WM%22">Linehan WM</searchLink>; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Kummar+S%22">Kummar S</searchLink>; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Doroshow+JH%22">Doroshow JH</searchLink>; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, United States of America.; Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Parchment+RE%22">Parchment RE</searchLink>; Clinical Pharmacodynamic Biomarkers Program, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2026 May 12; Vol. 21 (5), pp. e0349090. <i>Date of Electronic Publication: </i>2026 May 12 (<i>Print Publication: </i>2026).
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