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Bcl-2 upregulates calcium efflux through PMCA and NCX1 to preserve intracellular calcium homeostasis and confer resistance to apoptosis.

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Title: Bcl-2 upregulates calcium efflux through PMCA and NCX1 to preserve intracellular calcium homeostasis and confer resistance to apoptosis.
Authors: Lin TC; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 701, Taiwan., Lee MJ; Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan., Nguyen NT; Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan., Hsiao SC; Department of Hematology & Oncology, Saint Martin de Porres Hospital, Chiayi 600, Taiwan., Chen YC; Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, New Taipei City 235603, Taiwan., Chen LH; University Center for Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan., Visitsattapongse S; Department of Biomedical Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand., Chiu WT; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 701, Taiwan; Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan; Medical Device Innovation Center, National Cheng Kung University, Tainan 701, Taiwan. Electronic address: wtchiu@mail.ncku.edu.tw.
Source: Cell calcium [Cell Calcium] 2026 May 10; Vol. 136, pp. 103151. Date of Electronic Publication: 2026 May 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8006226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1991 (Electronic) Linking ISSN: 01434160 NLM ISO Abbreviation: Cell Calcium Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Bcl-2 upregulates calcium efflux through PMCA and NCX1 to preserve intracellular calcium homeostasis and confer resistance to apoptosis.
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  Data: <searchLink fieldCode="AU" term="%22Lin+TC%22">Lin TC</searchLink>; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 701, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+MJ%22">Lee MJ</searchLink>; Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan.<br /><searchLink fieldCode="AU" term="%22Nguyen+NT%22">Nguyen NT</searchLink>; Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsiao+SC%22">Hsiao SC</searchLink>; Department of Hematology & Oncology, Saint Martin de Porres Hospital, Chiayi 600, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, New Taipei City 235603, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+LH%22">Chen LH</searchLink>; University Center for Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan.<br /><searchLink fieldCode="AU" term="%22Visitsattapongse+S%22">Visitsattapongse S</searchLink>; Department of Biomedical Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.<br /><searchLink fieldCode="AU" term="%22Chiu+WT%22">Chiu WT</searchLink>; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 701, Taiwan; Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan; Medical Device Innovation Center, National Cheng Kung University, Tainan 701, Taiwan. Electronic address: wtchiu@mail.ncku.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%228006226%22">Cell calcium</searchLink> [Cell Calcium] 2026 May 10; Vol. 136, pp. 103151. <i>Date of Electronic Publication: </i>2026 May 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8006226 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-1991 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201434160%22">01434160 </searchLink><i>NLM ISO Abbreviation: </i>Cell Calcium <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ceca.2026.103151
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      – Code: eng
        Text: English
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        StartPage: 103151
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      – TitleFull: Bcl-2 upregulates calcium efflux through PMCA and NCX1 to preserve intracellular calcium homeostasis and confer resistance to apoptosis.
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            – D: 10
              M: 05
              Text: 2026 May 10
              Type: published
              Y: 2026
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