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Pseudomonas aeruginosa 3-oxo-C12HSL-induced apoptosis involves bitter taste receptor T2R14 and the mitochondrial calcium uniporter.

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Title: Pseudomonas aeruginosa 3-oxo-C12HSL-induced apoptosis involves bitter taste receptor T2R14 and the mitochondrial calcium uniporter.
Authors: Miller ZA; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA; Pharmacology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. Electronic address: zoeym@pennmedicine.upenn.edu., Mueller A; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Thompson JC; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Williams JS; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA; Pharmacology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Park A; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Darwich NF; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Kouakou YI; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Sywanycz SM; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Buchler BL; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Adappa ND; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Palmer JN; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Cohen NA; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA; Corporal Michael J. Crescenz Philadelphia VA Medical Center, USA; Monell Chemical Senses Center, USA., Carey RM; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Lee RJ; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA; Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. Electronic address: rjl@pennmedicine.upenn.edu.
Source: Cell calcium [Cell Calcium] 2026 May 05; Vol. 136, pp. 103141. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8006226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1991 (Electronic) Linking ISSN: 01434160 NLM ISO Abbreviation: Cell Calcium Subsets: MEDLINE
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  Data: Pseudomonas aeruginosa 3-oxo-C12HSL-induced apoptosis involves bitter taste receptor T2R14 and the mitochondrial calcium uniporter.
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  Data: <searchLink fieldCode="AU" term="%22Miller+ZA%22">Miller ZA</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA; Pharmacology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. Electronic address: zoeym@pennmedicine.upenn.edu.<br /><searchLink fieldCode="AU" term="%22Mueller+A%22">Mueller A</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+JC%22">Thompson JC</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Williams+JS%22">Williams JS</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA; Pharmacology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Park+A%22">Park A</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Darwich+NF%22">Darwich NF</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Kouakou+YI%22">Kouakou YI</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Sywanycz+SM%22">Sywanycz SM</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Buchler+BL%22">Buchler BL</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Adappa+ND%22">Adappa ND</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Palmer+JN%22">Palmer JN</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+NA%22">Cohen NA</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA; Corporal Michael J. Crescenz Philadelphia VA Medical Center, USA; Monell Chemical Senses Center, USA.<br /><searchLink fieldCode="AU" term="%22Carey+RM%22">Carey RM</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Lee+RJ%22">Lee RJ</searchLink>; Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA; Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. Electronic address: rjl@pennmedicine.upenn.edu.
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  Data: <searchLink fieldCode="JN" term="%228006226%22">Cell calcium</searchLink> [Cell Calcium] 2026 May 05; Vol. 136, pp. 103141. <i>Date of Electronic Publication: </i>2026 May 05.
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              Text: 2026 May 05
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