S-Adenosylhomocysteine hydrolase inhibitor DZ2002 promotes diabetic wound healing by regulating Macrophage-Mediated inflammation through the mixed lineage leukemia 1-H3K4me3 axis.
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| Title: | S-Adenosylhomocysteine hydrolase inhibitor DZ2002 promotes diabetic wound healing by regulating Macrophage-Mediated inflammation through the mixed lineage leukemia 1-H3K4me3 axis. |
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| Authors: | Wang YL; The Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Wang HL; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China., Hao YZ; The Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Zhu QY; The Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Yang XQ; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Feng CL; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Tang W; The Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: tangwei@simm.ac.cn. |
| Source: | Biochemical pharmacology [Biochem Pharmacol] 2026 Aug; Vol. 250 (Pt 2), pp. 118044. Date of Electronic Publication: 2026 May 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42119676 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: S-Adenosylhomocysteine hydrolase inhibitor DZ2002 promotes diabetic wound healing by regulating Macrophage-Mediated inflammation through the mixed lineage leukemia 1-H3K4me3 axis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Wang+YL%22">Wang YL</searchLink>; The Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Wang+HL%22">Wang HL</searchLink>; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Hao+YZ%22">Hao YZ</searchLink>; The Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhu+QY%22">Zhu QY</searchLink>; The Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Yang+XQ%22">Yang XQ</searchLink>; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Feng+CL%22">Feng CL</searchLink>; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Tang+W%22">Tang W</searchLink>; The Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: tangwei@simm.ac.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220101032%22">Biochemical pharmacology</searchLink> [Biochem Pharmacol] 2026 Aug; Vol. 250 (Pt 2), pp. 118044. <i>Date of Electronic Publication: </i>2026 May 10. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0101032 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-2968 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200062952%22">00062952 </searchLink><i>NLM ISO Abbreviation: </i>Biochem Pharmacol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42119676 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.bcp.2026.118044 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 118044 Titles: – TitleFull: S-Adenosylhomocysteine hydrolase inhibitor DZ2002 promotes diabetic wound healing by regulating Macrophage-Mediated inflammation through the mixed lineage leukemia 1-H3K4me3 axis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang YL – PersonEntity: Name: NameFull: Wang HL – PersonEntity: Name: NameFull: Hao YZ – PersonEntity: Name: NameFull: Zhu QY – PersonEntity: Name: NameFull: Yang XQ – PersonEntity: Name: NameFull: Feng CL – PersonEntity: Name: NameFull: Tang W IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2026 Aug Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1873-2968 Numbering: – Type: volume Value: 250 – Type: issue Value: Pt 2 Titles: – TitleFull: Biochemical pharmacology Type: main |
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