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CRISPR screen uncovers SLC26A2 as a modulator of tungsten toxicity in endochondral ossification.

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Title: CRISPR screen uncovers SLC26A2 as a modulator of tungsten toxicity in endochondral ossification.
Authors: Bakadlag R; Division of Clinical and Translational Research, McGill University, Montreal, Quebec, H4A 3J1, Canada; Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, H3T1E2, Canada., Li S; Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, H3T1E2, Canada., Guilbert C; Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, H3T1E2, Canada., Huard C; Institute for Research in Immunology and Cancer, Department of Medicine, University of Montreal, Montreal, Quebec, H3T 1J4, Canada., Bertomeu T; Institute for Research in Immunology and Cancer, Department of Medicine, University of Montreal, Montreal, Quebec, H3T 1J4, Canada; ChemoGenix, The Pooled Genome-wide KO CRISPR Cas9 Screening Facility of IRIC, University of Montreal, Montreal, Quebec, H3T 1J4, Canada., Coulombe-Huntington J; Department of Bioengineering, McGill University, Montreal, Quebec, H3A 0E9, Canada., Jackson BP; Department of Earth Science, Dartmouth College, Hanover, NH, 03755, United States., Grant MP; Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, H3T1E2, Canada., Iskandarani L; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 0B1, Canada., Paganini C; Center for Inherited Diseases, Department of Research, Fondazione. I.R.C.C.S. Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Pavia, 27100, Italy., Rossi A; Department of Molecular Medicine, University of Pavia, Pavia, 27100, Italy., Mwale F; Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, H3T1E2, Canada; Department of Surgical and Interventional Sciences, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, H3T 1E2, Canada., Tyers M; Program in Molecular Medicine, The Hospital for Sick Children, 686 Bay Street, Toronto, Ontario, M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Hales BF; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 0B1, Canada., Mann KK; Division of Clinical and Translational Research, McGill University, Montreal, Quebec, H4A 3J1, Canada; Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, H3T1E2, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 0B1, Canada. Electronic address: Koren.mann@mcgill.ca.
Source: Environmental research [Environ Res] 2026 Aug 15; Vol. 303 (Pt 1), pp. 124634. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CRISPR screen uncovers SLC26A2 as a modulator of tungsten toxicity in endochondral ossification.
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  Data: <searchLink fieldCode="AU" term="%22Bakadlag+R%22">Bakadlag R</searchLink>; Division of Clinical and Translational Research, McGill University, Montreal, Quebec, H4A 3J1, Canada; Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, H3T1E2, Canada.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, H3T1E2, Canada.<br /><searchLink fieldCode="AU" term="%22Guilbert+C%22">Guilbert C</searchLink>; Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, H3T1E2, Canada.<br /><searchLink fieldCode="AU" term="%22Huard+C%22">Huard C</searchLink>; Institute for Research in Immunology and Cancer, Department of Medicine, University of Montreal, Montreal, Quebec, H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Bertomeu+T%22">Bertomeu T</searchLink>; Institute for Research in Immunology and Cancer, Department of Medicine, University of Montreal, Montreal, Quebec, H3T 1J4, Canada; ChemoGenix, The Pooled Genome-wide KO CRISPR Cas9 Screening Facility of IRIC, University of Montreal, Montreal, Quebec, H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Coulombe-Huntington+J%22">Coulombe-Huntington J</searchLink>; Department of Bioengineering, McGill University, Montreal, Quebec, H3A 0E9, Canada.<br /><searchLink fieldCode="AU" term="%22Jackson+BP%22">Jackson BP</searchLink>; Department of Earth Science, Dartmouth College, Hanover, NH, 03755, United States.<br /><searchLink fieldCode="AU" term="%22Grant+MP%22">Grant MP</searchLink>; Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, H3T1E2, Canada.<br /><searchLink fieldCode="AU" term="%22Iskandarani+L%22">Iskandarani L</searchLink>; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 0B1, Canada.<br /><searchLink fieldCode="AU" term="%22Paganini+C%22">Paganini C</searchLink>; Center for Inherited Diseases, Department of Research, Fondazione. I.R.C.C.S. Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Pavia, 27100, Italy.<br /><searchLink fieldCode="AU" term="%22Rossi+A%22">Rossi A</searchLink>; Department of Molecular Medicine, University of Pavia, Pavia, 27100, Italy.<br /><searchLink fieldCode="AU" term="%22Mwale+F%22">Mwale F</searchLink>; Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, H3T1E2, Canada; Department of Surgical and Interventional Sciences, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, H3T 1E2, Canada.<br /><searchLink fieldCode="AU" term="%22Tyers+M%22">Tyers M</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children, 686 Bay Street, Toronto, Ontario, M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Hales+BF%22">Hales BF</searchLink>; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 0B1, Canada.<br /><searchLink fieldCode="AU" term="%22Mann+KK%22">Mann KK</searchLink>; Division of Clinical and Translational Research, McGill University, Montreal, Quebec, H4A 3J1, Canada; Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, H3T1E2, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 0B1, Canada. Electronic address: Koren.mann@mcgill.ca.
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              Text: 2026 Aug 15
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