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An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection.

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Title: An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection.
Authors: Lebon S; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Habshush Menachem A; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Davidzohn N; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Katz A; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Wigoda N; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Braun T; Sheba Medical Center, Tel-Hashomer, Affiliated with Tel Aviv University, Tel Aviv, Israel., Yahalomi D; Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel., Rotkopf R; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Holiar V; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Dadosh T; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel., Levin-Zaidman S; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel., Dezorella N; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel., Goliand I; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Kupervaser M; de Botton Institute for Protein Profiling, The Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel., Leebhoff S; The Hadassah Organoid Center, the Hadassah-Hebrew University Medical Organization, Jerusalem, Israel., Blumberger N; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Hoffman D; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Grunewald M; The Hadassah Organoid Center, the Hadassah-Hebrew University Medical Organization, Jerusalem, Israel., Levin Y; de Botton Institute for Protein Profiling, The Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel., Haberman Y; Sheba Medical Center, Tel-Hashomer, Affiliated with Tel Aviv University, Tel Aviv, Israel.; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Hofree M; Lautenberg Center for Immunology and Cancer Research, Institute of Medical Research, Hebrew University of Jerusalem, Jerusalem, Israel. matan.hofree@mail.huji.ac.il.; School of Computer Science and Engineering, Hebrew University of Jerusalem, Jerusalem, Israel. matan.hofree@mail.huji.ac.il., Biton M; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel. moshe.biton@weizmann.ac.il.
Source: Nature immunology [Nat Immunol] 2026 Jul; Vol. 27 (7), pp. 1404-1417. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection.
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  Data: <searchLink fieldCode="AU" term="%22Lebon+S%22">Lebon S</searchLink>; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Habshush+Menachem+A%22">Habshush Menachem A</searchLink>; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Davidzohn+N%22">Davidzohn N</searchLink>; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Katz+A%22">Katz A</searchLink>; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Wigoda+N%22">Wigoda N</searchLink>; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Braun+T%22">Braun T</searchLink>; Sheba Medical Center, Tel-Hashomer, Affiliated with Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Yahalomi+D%22">Yahalomi D</searchLink>; Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Rotkopf+R%22">Rotkopf R</searchLink>; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Holiar+V%22">Holiar V</searchLink>; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Dadosh+T%22">Dadosh T</searchLink>; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Levin-Zaidman+S%22">Levin-Zaidman S</searchLink>; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Dezorella+N%22">Dezorella N</searchLink>; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Goliand+I%22">Goliand I</searchLink>; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Kupervaser+M%22">Kupervaser M</searchLink>; de Botton Institute for Protein Profiling, The Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Leebhoff+S%22">Leebhoff S</searchLink>; The Hadassah Organoid Center, the Hadassah-Hebrew University Medical Organization, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Blumberger+N%22">Blumberger N</searchLink>; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Hoffman+D%22">Hoffman D</searchLink>; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Grunewald+M%22">Grunewald M</searchLink>; The Hadassah Organoid Center, the Hadassah-Hebrew University Medical Organization, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Levin+Y%22">Levin Y</searchLink>; de Botton Institute for Protein Profiling, The Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Haberman+Y%22">Haberman Y</searchLink>; Sheba Medical Center, Tel-Hashomer, Affiliated with Tel Aviv University, Tel Aviv, Israel.; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hofree+M%22">Hofree M</searchLink>; Lautenberg Center for Immunology and Cancer Research, Institute of Medical Research, Hebrew University of Jerusalem, Jerusalem, Israel. matan.hofree@mail.huji.ac.il.; School of Computer Science and Engineering, Hebrew University of Jerusalem, Jerusalem, Israel. matan.hofree@mail.huji.ac.il.<br /><searchLink fieldCode="AU" term="%22Biton+M%22">Biton M</searchLink>; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel. moshe.biton@weizmann.ac.il.
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  Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2026 Jul; Vol. 27 (7), pp. 1404-1417. <i>Date of Electronic Publication: </i>2026 May 12.
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