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Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial.

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Title: Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial.
Authors: Garfinkle EAR; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA., Perales-Linares R; Geneos Therapeutics, Philadelphia, PA, USA., Gimple RC; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Livingstone AJ; Division of Medical Oncology, Washington University School of Medicine, St. Louis, MO, USA., Roberts KF; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Butt OH; Division of Medical Oncology, Washington University School of Medicine, St. Louis, MO, USA.; The Brain Tumor Center at Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Goedegebuure SP; The Brain Tumor Center at Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Surgery, Washington University in St. Louis, St. Louis, MO, USA., McLellan MD; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Chang GS; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Hundal J; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Yan J; Geneos Therapeutics, Philadelphia, PA, USA., Navarro JB; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA., Paxton SA; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; Biomedical Sciences Graduate Program, The Ohio State University College of Medicine, Columbus, OH, USA., Chattopadhyay S; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; The Ohio State University, Columbus, OH, USA., Cooch N; Geneos Therapeutics, Philadelphia, PA, USA., Perales-Puchalt A; Geneos Therapeutics, Philadelphia, PA, USA., Stavroulaki K; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA., Rochestie S; Geneos Therapeutics, Philadelphia, PA, USA., Peters J; Geneos Therapeutics, Philadelphia, PA, USA., Junker B; BioProcess Advantage LLC, Westfield, NJ, USA., Campian JL; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Chheda MG; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; The Brain Tumor Center at Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Chicoine MR; Department of Neurosurgery, University of Missouri, Columbia, MO, USA., Kim AH; The Brain Tumor Center at Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA., Willie JT; Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA., Zipfel GJ; The Brain Tumor Center at Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA., Dowling JL; The Brain Tumor Center at Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO, USA., Miller CA; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Griffith OL; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Griffith M; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Gillanders WE; Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA., Miller KE; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA., Mardis ER; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA., Sardesai NY; Geneos Therapeutics, Philadelphia, PA, USA., Dunn GP; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Johanns TM; Division of Medical Oncology, Washington University School of Medicine, St. Louis, MO, USA. tannerjohanns@wustl.edu.; The Brain Tumor Center at Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. tannerjohanns@wustl.edu.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Program, Washington University School of Medicine, St. Louis, MO, USA. tannerjohanns@wustl.edu.
Source: Nature cancer [Nat Cancer] 2026 May 12. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Program, Washington University School of Medicine, St. Louis, MO, USA. tannerjohanns@wustl.edu.
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