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Affinity enhancement of an anti-VEGF humanized nanobody as a superior candidate to bevacizumab: integrative in silico and in vitro studies.

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Title: Affinity enhancement of an anti-VEGF humanized nanobody as a superior candidate to bevacizumab: integrative in silico and in vitro studies.
Authors: Kazemi MS; Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory, Pasteur Institute of Iran, Tehran, Iran.; Student Research Committee, Pasteur Institute of Iran, Tehran, Iran., Arab SS; Center of Molecular Medicine, Georgia University, Athens, GA, 30602, USA., Kazemi-Lomedasht F; Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory, Pasteur Institute of Iran, Tehran, Iran., Ahangari Cohan R; Nanobiotechnology Department, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran., Zandi F; Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran., Shoari A; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA., Hosseininejad-Chafi M; Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory, Pasteur Institute of Iran, Tehran, Iran., Mahjoobi G; Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory, Pasteur Institute of Iran, Tehran, Iran., Ashja Ardalan A; Department of Pharmacy and Biotechnology, University of Bologna, 40126, Bologna, Italy., Kanavi MR; Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. rezaeikanavi@gmail.com., Behdani M; Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory, Pasteur Institute of Iran, Tehran, Iran. behdani@pasteur.ac.ir.
Source: BMC biotechnology [BMC Biotechnol] 2026 May 12; Vol. 26 (1). Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101088663 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6750 (Electronic) Linking ISSN: 14726750 NLM ISO Abbreviation: BMC Biotechnol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Affinity enhancement of an anti-VEGF humanized nanobody as a superior candidate to bevacizumab: integrative in silico and in vitro studies.
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  Data: <searchLink fieldCode="AU" term="%22Kazemi+MS%22">Kazemi MS</searchLink>; Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory, Pasteur Institute of Iran, Tehran, Iran.; Student Research Committee, Pasteur Institute of Iran, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Arab+SS%22">Arab SS</searchLink>; Center of Molecular Medicine, Georgia University, Athens, GA, 30602, USA.<br /><searchLink fieldCode="AU" term="%22Kazemi-Lomedasht+F%22">Kazemi-Lomedasht F</searchLink>; Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory, Pasteur Institute of Iran, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Ahangari+Cohan+R%22">Ahangari Cohan R</searchLink>; Nanobiotechnology Department, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Zandi+F%22">Zandi F</searchLink>; Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Shoari+A%22">Shoari A</searchLink>; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Hosseininejad-Chafi+M%22">Hosseininejad-Chafi M</searchLink>; Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory, Pasteur Institute of Iran, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Mahjoobi+G%22">Mahjoobi G</searchLink>; Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory, Pasteur Institute of Iran, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Ashja+Ardalan+A%22">Ashja Ardalan A</searchLink>; Department of Pharmacy and Biotechnology, University of Bologna, 40126, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Kanavi+MR%22">Kanavi MR</searchLink>; Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. rezaeikanavi@gmail.com.<br /><searchLink fieldCode="AU" term="%22Behdani+M%22">Behdani M</searchLink>; Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory, Pasteur Institute of Iran, Tehran, Iran. behdani@pasteur.ac.ir.
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  Data: <searchLink fieldCode="JN" term="%22101088663%22">BMC biotechnology</searchLink> [BMC Biotechnol] 2026 May 12; Vol. 26 (1). <i>Date of Electronic Publication: </i>2026 May 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101088663 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1472-6750 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214726750%22">14726750 </searchLink><i>NLM ISO Abbreviation: </i>BMC Biotechnol <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12896-026-01165-7
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              Text: 2026 May 12
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