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Deep learning-based 3D leukocyte differentiation using label-free higher harmonic generation microscopy.

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Title: Deep learning-based 3D leukocyte differentiation using label-free higher harmonic generation microscopy.
Authors: Zhou M; Faculty of Science, Department of Physics, Laserlab, Vrije Universiteit Amsterdam, De Boelelaan, Amsterdam, 1105, 1081HV, The Netherlands. mengyao.zhou@maastrichtuniversity.nl.; Department of Genetics and Cell Biology, MHeNs -Research Institute for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, 6229 ER, The Netherlands. mengyao.zhou@maastrichtuniversity.nl., González PJ; Faculty of Science, Department of Physics, Laserlab, Vrije Universiteit Amsterdam, De Boelelaan, Amsterdam, 1105, 1081HV, The Netherlands., Dekker T; Department of Experimental Immunology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Infection & Immunity, Inflammatory Diseases, Amsterdam, The Netherlands., Zhang S; Intensive Care Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands., Boers LS; Intensive Care Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands., van den Heuvel HB; Intensive Care Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands., Dijkhuis A; Department of Experimental Immunology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Infection & Immunity, Inflammatory Diseases, Amsterdam, The Netherlands.; Department of Pulmonary Medicine, Amsterdam UMC, Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Simons IA; Department of Experimental Immunology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Infection & Immunity, Inflammatory Diseases, Amsterdam, The Netherlands.; Department of Pulmonary Medicine, Amsterdam UMC, Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Duitman JW; Department of Experimental Immunology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Infection & Immunity, Inflammatory Diseases, Amsterdam, The Netherlands.; Department of Pulmonary Medicine, Amsterdam UMC, Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Groot ML; Faculty of Science, Department of Physics, Laserlab, Vrije Universiteit Amsterdam, De Boelelaan, Amsterdam, 1105, 1081HV, The Netherlands.
Source: Journal of translational medicine [J Transl Med] 2026 May 12; Vol. 24 (1). Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1479-5876
DOI:10.1186/s12967-026-08225-8