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The Synthetic Cannabinoid AKB-48 Induces Cell Death in Murine Cerebellum Through Different Signaling Pathways.

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Title: The Synthetic Cannabinoid AKB-48 Induces Cell Death in Murine Cerebellum Through Different Signaling Pathways.
Authors: De Luca F; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Corli G; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy., Bassi M; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy., Bilel S; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy., Merli D; Department of Chemistry, University of Pavia, Viale Taramelli 10, 27100 Pavia, Italy.; INFN Sezione di Milano-Bicocca, Piazza della Scienza 3, 20126 Milano, Italy., Lonati D; Laboratory of Clinical and Experimental Toxicology, and Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Via Maugeri 10, 27100 Pavia, Italy., Schicchi A; Laboratory of Clinical and Experimental Toxicology, and Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Via Maugeri 10, 27100 Pavia, Italy., Rossi P; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Bottone MG; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Locatelli CA; Laboratory of Clinical and Experimental Toxicology, and Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Via Maugeri 10, 27100 Pavia, Italy., Marti M; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.; Collaborative Center for the Italian National Early Warning System, NEWS-D, Department of Anti-Drug Policies and Other Addictions, Presidency of the Council of Ministers, 00186 Rome, Italy., Roda E; Laboratory of Clinical and Experimental Toxicology, and Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Via Maugeri 10, 27100 Pavia, Italy.
Source: International journal of molecular sciences [Int J Mol Sci] 2026 Apr 27; Vol. 27 (9). Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22De+Luca+F%22">De Luca F</searchLink>; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Corli+G%22">Corli G</searchLink>; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Bassi+M%22">Bassi M</searchLink>; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Bilel+S%22">Bilel S</searchLink>; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Merli+D%22">Merli D</searchLink>; Department of Chemistry, University of Pavia, Viale Taramelli 10, 27100 Pavia, Italy.; INFN Sezione di Milano-Bicocca, Piazza della Scienza 3, 20126 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Lonati+D%22">Lonati D</searchLink>; Laboratory of Clinical and Experimental Toxicology, and Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Via Maugeri 10, 27100 Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Schicchi+A%22">Schicchi A</searchLink>; Laboratory of Clinical and Experimental Toxicology, and Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Via Maugeri 10, 27100 Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Rossi+P%22">Rossi P</searchLink>; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Bottone+MG%22">Bottone MG</searchLink>; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Locatelli+CA%22">Locatelli CA</searchLink>; Laboratory of Clinical and Experimental Toxicology, and Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Via Maugeri 10, 27100 Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Marti+M%22">Marti M</searchLink>; Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy.; Collaborative Center for the Italian National Early Warning System, NEWS-D, Department of Anti-Drug Policies and Other Addictions, Presidency of the Council of Ministers, 00186 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Roda+E%22">Roda E</searchLink>; Laboratory of Clinical and Experimental Toxicology, and Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Via Maugeri 10, 27100 Pavia, Italy.
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