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Immunomodulators, associated or not with systemic antibiotics, to treat periodontitis: A 1-year multicenter, placebo-controlled, double-blind, randomized clinical trial.

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Title: Immunomodulators, associated or not with systemic antibiotics, to treat periodontitis: A 1-year multicenter, placebo-controlled, double-blind, randomized clinical trial.
Authors: Castro Dos Santos NC; Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil., Silva RNB; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil., Colombo FS; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil., Oliveira-Cardoso I; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil., Súarez LJ; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.; Departamento de Ciencias Básicas y Medicina Oral, Universidad Nacional de Colombia, Bogotá, Colombia.; Centro de Investigaciones Odontológicas, Pontificia Universidad Javeriana, Bogotá, Colombia., Martins R; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil., de Figueiredo LC; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil., Honório HM; Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil., Filho AML; School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Furlaneto FAC; School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Messora MR; School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Furukawa M; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil., Cortelli JR; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil., Rovai ES; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil.; Division of Periodontics, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, São Paulo, Brazil., Feres M; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.; Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Source: Journal of periodontology [J Periodontol] 2026 Jul; Vol. 97 (7), pp. 1454-1466. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Comparative Study
Journal Info: Publisher: American Academy of Periodontology Country of Publication: United States NLM ID: 8000345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-3670 (Electronic) Linking ISSN: 00223492 NLM ISO Abbreviation: J Periodontol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Immunomodulators, associated or not with systemic antibiotics, to treat periodontitis: A 1-year multicenter, placebo-controlled, double-blind, randomized clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Castro+Dos+Santos+NC%22">Castro Dos Santos NC</searchLink>; Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+RNB%22">Silva RNB</searchLink>; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Colombo+FS%22">Colombo FS</searchLink>; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Oliveira-Cardoso+I%22">Oliveira-Cardoso I</searchLink>; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Súarez+LJ%22">Súarez LJ</searchLink>; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.; Departamento de Ciencias Básicas y Medicina Oral, Universidad Nacional de Colombia, Bogotá, Colombia.; Centro de Investigaciones Odontológicas, Pontificia Universidad Javeriana, Bogotá, Colombia.<br /><searchLink fieldCode="AU" term="%22Martins+R%22">Martins R</searchLink>; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Figueiredo+LC%22">de Figueiredo LC</searchLink>; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Honório+HM%22">Honório HM</searchLink>; Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Filho+AML%22">Filho AML</searchLink>; School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Furlaneto+FAC%22">Furlaneto FAC</searchLink>; School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Messora+MR%22">Messora MR</searchLink>; School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Furukawa+M%22">Furukawa M</searchLink>; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Cortelli+JR%22">Cortelli JR</searchLink>; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Rovai+ES%22">Rovai ES</searchLink>; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil.; Division of Periodontics, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Feres+M%22">Feres M</searchLink>; Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.; Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Harvard Medical School, Boston, Massachusetts, USA.
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  Data: <searchLink fieldCode="JN" term="%228000345%22">Journal of periodontology</searchLink> [J Periodontol] 2026 Jul; Vol. 97 (7), pp. 1454-1466. <i>Date of Electronic Publication: </i>2026 May 12.
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  Data: Journal Article; Randomized Controlled Trial; Multicenter Study; Comparative Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Academy+of+Periodontology%22">American Academy of Periodontology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8000345 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1943-3670 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200223492%22">00223492 </searchLink><i>NLM ISO Abbreviation: </i>J Periodontol <i>Subsets: </i>MEDLINE
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        Value: 10.1002/jper.70081
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        Text: English
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              Text: 2026 Jul
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