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Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs.

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Title: Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs.
Authors: Day-Riley S; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, United Kingdom., Krajcovicova S; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, United Kingdom.; Department of Organic Chemistry, Faculty of Science, Palacky University, Tr. 17. Listopadu 12, Olomouc, 77900, Czech Republic., Sokhal AR; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, United Kingdom., Venne JL; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, United Kingdom., Brear P; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, United Kingdom., Hyvönen M; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, United Kingdom., Whitehurst BC; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge, CB2 0AA, United Kingdom., Carroll JS; Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, United Kingdom., Spring DR; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, United Kingdom.
Source: Beilstein journal of organic chemistry [Beilstein J Org Chem] 2026 Apr 22; Vol. 22, pp. 611-619. Date of Electronic Publication: 2026 Apr 22 (Print Publication: 2026).
Publication Type: Letter
Journal Info: Publisher: Beilstein-Institut Country of Publication: Germany NLM ID: 101250746 Publication Model: eCollection Cited Medium: Print ISSN: 1860-5397 (Print) Linking ISSN: 18605397 NLM ISO Abbreviation: Beilstein J Org Chem Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs.
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  Data: <searchLink fieldCode="AU" term="%22Day-Riley+S%22">Day-Riley S</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Krajcovicova+S%22">Krajcovicova S</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, United Kingdom.; Department of Organic Chemistry, Faculty of Science, Palacky University, Tr. 17. Listopadu 12, Olomouc, 77900, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Sokhal+AR%22">Sokhal AR</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Venne+JL%22">Venne JL</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Brear+P%22">Brear P</searchLink>; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hyvönen+M%22">Hyvönen M</searchLink>; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Whitehurst+BC%22">Whitehurst BC</searchLink>; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge, CB2 0AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Carroll+JS%22">Carroll JS</searchLink>; Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Spring+DR%22">Spring DR</searchLink>; Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, United Kingdom.
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  Data: <searchLink fieldCode="JN" term="%22101250746%22">Beilstein journal of organic chemistry</searchLink> [Beilstein J Org Chem] 2026 Apr 22; Vol. 22, pp. 611-619. <i>Date of Electronic Publication: </i>2026 Apr 22 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Beilstein-Institut%22">Beilstein-Institut </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101250746 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1860-5397 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218605397%22">18605397 </searchLink><i>NLM ISO Abbreviation: </i>Beilstein J Org Chem <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Apr 22
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