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Low-dose IL-2 fails to expand Tregs after alemtuzumab: insight into impaired immune tolerance in multiple sclerosis.

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Title: Low-dose IL-2 fails to expand Tregs after alemtuzumab: insight into impaired immune tolerance in multiple sclerosis.
Authors: Georgieva ZG; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Howlett SK; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Rainbow DB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Coppard V; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Ellis L; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Jarvis LB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Williams E; Department of Immunobiology, King's College London, London, SE1 9RT, UK., Yang JHM; Department of Immunobiology, King's College London, London, SE1 9RT, UK., Sun B; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Tree T; Department of Immunobiology, King's College London, London, SE1 9RT, UK., Coles AJ; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK., Wicker LS; Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, OX3 7BN, UK., Jones JL; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.
Source: Brain : a journal of neurology [Brain] 2026 May 13. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Low-dose IL-2 fails to expand Tregs after alemtuzumab: insight into impaired immune tolerance in multiple sclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Georgieva+ZG%22">Georgieva ZG</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Howlett+SK%22">Howlett SK</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Rainbow+DB%22">Rainbow DB</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Coppard+V%22">Coppard V</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Ellis+L%22">Ellis L</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Jarvis+LB%22">Jarvis LB</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Williams+E%22">Williams E</searchLink>; Department of Immunobiology, King's College London, London, SE1 9RT, UK.<br /><searchLink fieldCode="AU" term="%22Yang+JHM%22">Yang JHM</searchLink>; Department of Immunobiology, King's College London, London, SE1 9RT, UK.<br /><searchLink fieldCode="AU" term="%22Sun+B%22">Sun B</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Tree+T%22">Tree T</searchLink>; Department of Immunobiology, King's College London, London, SE1 9RT, UK.<br /><searchLink fieldCode="AU" term="%22Coles+AJ%22">Coles AJ</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Wicker+LS%22">Wicker LS</searchLink>; Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Jones+JL%22">Jones JL</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0372537 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1460-2156 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200068950%22">00068950 </searchLink><i>NLM ISO Abbreviation: </i>Brain <i>Subsets: </i>MEDLINE
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        Value: 10.1093/brain/awag171
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              Text: 2026 May 13
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