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Astrocyte reactivity across the AD continuum measured by [18F]SMBT-1 and its relationship with the Aβ burden.

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Title: Astrocyte reactivity across the AD continuum measured by [18F]SMBT-1 and its relationship with the Aβ burden.
Authors: Wu Y; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan., Hiraoka K; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku University Hospital, Tohoku University, Sendai, Japan., Mesfin B; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan., Kikuchi A; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku University Hospital, Tohoku University, Sendai, Japan., Watanuki S; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku University Hospital, Tohoku University, Sendai, Japan., Mugikura S; Tohoku University Hospital, Tohoku University, Sendai, Japan., Tomita N; Tohoku University Hospital, Tohoku University, Sendai, Japan.; Tohoku Medical and Pharmaceutical University, Sendai, Japan., Ishiki A; Tohoku University Hospital, Tohoku University, Sendai, Japan.; Tohoku Medical and Pharmaceutical University, Sendai, Japan., Furukawa K; Tohoku University Hospital, Tohoku University, Sendai, Japan.; Tohoku Medical and Pharmaceutical University, Sendai, Japan., Funaki Y; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku University Hospital, Tohoku University, Sendai, Japan., Toyohara J; Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Kimura Y; National Center for Geriatrics and Gerontology, Obu, Japan., Harada R; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku Medical and Pharmaceutical University, Sendai, Japan., Furumoto S; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku University Hospital, Tohoku University, Sendai, Japan., Kikuchi A; Tohoku University Hospital, Tohoku University, Sendai, Japan.; Yamagata Prefectural University of Health Sciences, Yamagata, Japan., Watabe H; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku University Hospital, Tohoku University, Sendai, Japan., Kobayashi R; Yamagata University Hospital, Yamagata, Japan., Nihashi T; National Center for Geriatrics and Gerontology, Obu, Japan., Kato T; National Center for Geriatrics and Gerontology, Obu, Japan., Ishii K; Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Kawakatsu S; Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan., Okamura N; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku Medical and Pharmaceutical University, Sendai, Japan., Tashiro M; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan. manabu.tashiro.a2@tohoku.ac.jp.; Tohoku University Hospital, Tohoku University, Sendai, Japan. manabu.tashiro.a2@tohoku.ac.jp.
Corporate Authors: SMBTSD study project group*
Source: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2026 May 06. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Berlin Country of Publication: Germany NLM ID: 101140988 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-7089 (Electronic) Linking ISSN: 16197070 NLM ISO Abbreviation: Eur J Nucl Med Mol Imaging Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Astrocyte reactivity across the AD continuum measured by [<superscript>18</superscript>F]SMBT-1 and its relationship with the Aβ burden.
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  Data: <searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Hiraoka+K%22">Hiraoka K</searchLink>; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku University Hospital, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Mesfin+B%22">Mesfin B</searchLink>; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Kikuchi+A%22">Kikuchi A</searchLink>; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku University Hospital, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Watanuki+S%22">Watanuki S</searchLink>; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku University Hospital, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Mugikura+S%22">Mugikura S</searchLink>; Tohoku University Hospital, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Tomita+N%22">Tomita N</searchLink>; Tohoku University Hospital, Tohoku University, Sendai, Japan.; Tohoku Medical and Pharmaceutical University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Ishiki+A%22">Ishiki A</searchLink>; Tohoku University Hospital, Tohoku University, Sendai, Japan.; Tohoku Medical and Pharmaceutical University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Furukawa+K%22">Furukawa K</searchLink>; Tohoku University Hospital, Tohoku University, Sendai, Japan.; Tohoku Medical and Pharmaceutical University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Funaki+Y%22">Funaki Y</searchLink>; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku University Hospital, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Toyohara+J%22">Toyohara J</searchLink>; Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kimura+Y%22">Kimura Y</searchLink>; National Center for Geriatrics and Gerontology, Obu, Japan.<br /><searchLink fieldCode="AU" term="%22Harada+R%22">Harada R</searchLink>; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku Medical and Pharmaceutical University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Furumoto+S%22">Furumoto S</searchLink>; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku University Hospital, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Kikuchi+A%22">Kikuchi A</searchLink>; Tohoku University Hospital, Tohoku University, Sendai, Japan.; Yamagata Prefectural University of Health Sciences, Yamagata, Japan.<br /><searchLink fieldCode="AU" term="%22Watabe+H%22">Watabe H</searchLink>; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku University Hospital, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+R%22">Kobayashi R</searchLink>; Yamagata University Hospital, Yamagata, Japan.<br /><searchLink fieldCode="AU" term="%22Nihashi+T%22">Nihashi T</searchLink>; National Center for Geriatrics and Gerontology, Obu, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+T%22">Kato T</searchLink>; National Center for Geriatrics and Gerontology, Obu, Japan.<br /><searchLink fieldCode="AU" term="%22Ishii+K%22">Ishii K</searchLink>; Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kawakatsu+S%22">Kawakatsu S</searchLink>; Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan.<br /><searchLink fieldCode="AU" term="%22Okamura+N%22">Okamura N</searchLink>; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan.; Tohoku Medical and Pharmaceutical University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Tashiro+M%22">Tashiro M</searchLink>; Research Center for Accelerator and Radioisotope Science (RARiS), Tohoku University, 6-3 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8578, Japan. manabu.tashiro.a2@tohoku.ac.jp.; Tohoku University Hospital, Tohoku University, Sendai, Japan. manabu.tashiro.a2@tohoku.ac.jp.
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  Data: <searchLink fieldCode="CA" term="%22SMBTSD+study+project+group*%22">SMBTSD study project group*</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101140988%22">European journal of nuclear medicine and molecular imaging</searchLink> [Eur J Nucl Med Mol Imaging] 2026 May 06. <i>Date of Electronic Publication: </i>2026 May 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag+Berlin%22">Springer-Verlag Berlin </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101140988 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1619-7089 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216197070%22">16197070 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Nucl Med Mol Imaging <i>Subsets: </i>MEDLINE
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