Orlistat potentiates the gemcitabine effect in inhibiting the malignant biological behavior of nasopharyngeal carcinoma by downregulating PKM2.

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Title: Orlistat potentiates the gemcitabine effect in inhibiting the malignant biological behavior of nasopharyngeal carcinoma by downregulating PKM2.
Authors: Zhang P; Department of Otolaryngology, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China. chary444106@163.com., Cai Q; Shenshan Central Hospital, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei, Guangdong, China., Ouyang S; Department of Otolaryngology, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China. 13926128000@163.com.
Source: Discover oncology [Discov Oncol] 2026 May 13; Vol. 17 (1). Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101775142 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-6011 (Electronic) Linking ISSN: 27306011 NLM ISO Abbreviation: Discov Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2730-6011
DOI:10.1007/s12672-026-05186-8