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Nitazoxanide Exhibits Schistosomicidal Activity Against Schistosomula and Adult Schistosoma mansoni and Influences Praziquantel-Associated Outcomes.

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Title: Nitazoxanide Exhibits Schistosomicidal Activity Against Schistosomula and Adult Schistosoma mansoni and Influences Praziquantel-Associated Outcomes.
Authors: Da Costa CJ; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil. jadsoncosta02@gmail.com., Gama JEM; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil., Silva AJM; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil., Saraiva KLA; Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Technological Platforms Network, Electron Microscopy Platform, Pernambuco, Brazil., Peixoto CA; Department of Microbiology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Ultrastructure Laboratory of the Aggeu Magalhães Institute, Pernambuco, Brazil., de Araújo RE; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil., Filho CALM; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil., Albuquerque GHA; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil., Moura DMN; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil., De Oliveira SA; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil. sheilla.andrade@fiocruz.br.
Source: Acta parasitologica [Acta Parasitol] 2026 May 13; Vol. 71 (3). Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 9301947 Publication Model: Electronic Cited Medium: Internet ISSN: 1896-1851 (Electronic) Linking ISSN: 12302821 NLM ISO Abbreviation: Acta Parasitol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Da+Costa+CJ%22">Da Costa CJ</searchLink>; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil. jadsoncosta02@gmail.com.<br /><searchLink fieldCode="AU" term="%22Gama+JEM%22">Gama JEM</searchLink>; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+AJM%22">Silva AJM</searchLink>; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil.<br /><searchLink fieldCode="AU" term="%22Saraiva+KLA%22">Saraiva KLA</searchLink>; Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Technological Platforms Network, Electron Microscopy Platform, Pernambuco, Brazil.<br /><searchLink fieldCode="AU" term="%22Peixoto+CA%22">Peixoto CA</searchLink>; Department of Microbiology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Ultrastructure Laboratory of the Aggeu Magalhães Institute, Pernambuco, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Araújo+RE%22">de Araújo RE</searchLink>; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil.<br /><searchLink fieldCode="AU" term="%22Filho+CALM%22">Filho CALM</searchLink>; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil.<br /><searchLink fieldCode="AU" term="%22Albuquerque+GHA%22">Albuquerque GHA</searchLink>; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil.<br /><searchLink fieldCode="AU" term="%22Moura+DMN%22">Moura DMN</searchLink>; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil.<br /><searchLink fieldCode="AU" term="%22De+Oliveira+SA%22">De Oliveira SA</searchLink>; Department of Immunology, Laboratory of Immunopathology and Molecular Biology, Oswaldo Cruz Foundation (Fiocruz), Aggeu Magalhães Institute, Pernambuco, Brazil. sheilla.andrade@fiocruz.br.
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  Data: <searchLink fieldCode="JN" term="%229301947%22">Acta parasitologica</searchLink> [Acta Parasitol] 2026 May 13; Vol. 71 (3). <i>Date of Electronic Publication: </i>2026 May 13.
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