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Efficacy of buparlisib according to PIK3CA mutation status in recurrent or metastatic head and neck squamous cell carcinoma: A multicenter phase II trial.

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Title: Efficacy of buparlisib according to PIK3CA mutation status in recurrent or metastatic head and neck squamous cell carcinoma: A multicenter phase II trial.
Authors: Gauduchon T; Department of medical oncology, Centre Léon Bérard, Lyon, France. Electronic address: Thibault.gauduchon@lyon.unicancer.fr., Digue L; Department of medical oncology, Saint André Hospital Group, Bordeaux, France., Ferlay C; Direction of Clinical Research and Innovation, Centre Léon Bérard, Lyon, France., Treilleux I; Centre Léon Bérard, Lyon, France., Wang Q; Centre Léon Bérard, Lyon, France., Attignon V; Centre Léon Bérard, Lyon, France., Lefebvre G; Centre Oscar Lambret, Lille, France., Kotecki N; Department of Medical Oncology, Institut Jules Bordet, Bruxelles, Belgium., Daste A; Saint-André Hospital, Bordeaux, France., Even C; Institut Gustave Roussy, Villejuif, France., Couchon-Thaunat S; Centre Léon Bérard, Lyon, France., Guyennon A; Radiology department, Centre Léon Bérard, Lyon, France., Peyrade F; Department of medical oncology, Centre Antoine Lacassagne, Nice, France., Cupissol D; Department of medical oncology, Institut du Cancer de Montpellier, Montpellier, France., You B; Lyon Sud Hospital, Lyon, France., Tourneau CL; Institut Curie, Paris, France., Tabone-Eglinger S; Plateforme de Gestion des Echantillons Biologiques, Centre Léon Bérard, Cancer Research Center of Lyon, Université de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286 Lyon, France., Garin G; Direction of Clinical Research and Innovation, Centre Léon Bérard, Lyon, France., Pérol D; Direction of Clinical Research and Innovation, Centre Léon Bérard, Lyon, France., Fayette J; Department of medical oncology, Centre Léon Bérard, Lyon, France.
Source: Oral oncology [Oral Oncol] 2026 Jul; Vol. 178, pp. 108004. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9709118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0593 (Electronic) Linking ISSN: 13688375 NLM ISO Abbreviation: Oral Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy of buparlisib according to PIK3CA mutation status in recurrent or metastatic head and neck squamous cell carcinoma: A multicenter phase II trial.
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  Data: <searchLink fieldCode="AU" term="%22Gauduchon+T%22">Gauduchon T</searchLink>; Department of medical oncology, Centre Léon Bérard, Lyon, France. Electronic address: Thibault.gauduchon@lyon.unicancer.fr.<br /><searchLink fieldCode="AU" term="%22Digue+L%22">Digue L</searchLink>; Department of medical oncology, Saint André Hospital Group, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Ferlay+C%22">Ferlay C</searchLink>; Direction of Clinical Research and Innovation, Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Treilleux+I%22">Treilleux I</searchLink>; Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Attignon+V%22">Attignon V</searchLink>; Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Lefebvre+G%22">Lefebvre G</searchLink>; Centre Oscar Lambret, Lille, France.<br /><searchLink fieldCode="AU" term="%22Kotecki+N%22">Kotecki N</searchLink>; Department of Medical Oncology, Institut Jules Bordet, Bruxelles, Belgium.<br /><searchLink fieldCode="AU" term="%22Daste+A%22">Daste A</searchLink>; Saint-André Hospital, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Even+C%22">Even C</searchLink>; Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Couchon-Thaunat+S%22">Couchon-Thaunat S</searchLink>; Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Guyennon+A%22">Guyennon A</searchLink>; Radiology department, Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Peyrade+F%22">Peyrade F</searchLink>; Department of medical oncology, Centre Antoine Lacassagne, Nice, France.<br /><searchLink fieldCode="AU" term="%22Cupissol+D%22">Cupissol D</searchLink>; Department of medical oncology, Institut du Cancer de Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22You+B%22">You B</searchLink>; Lyon Sud Hospital, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Tourneau+CL%22">Tourneau CL</searchLink>; Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Tabone-Eglinger+S%22">Tabone-Eglinger S</searchLink>; Plateforme de Gestion des Echantillons Biologiques, Centre Léon Bérard, Cancer Research Center of Lyon, Université de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286 Lyon, France.<br /><searchLink fieldCode="AU" term="%22Garin+G%22">Garin G</searchLink>; Direction of Clinical Research and Innovation, Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Pérol+D%22">Pérol D</searchLink>; Direction of Clinical Research and Innovation, Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Fayette+J%22">Fayette J</searchLink>; Department of medical oncology, Centre Léon Bérard, Lyon, France.
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  Data: <searchLink fieldCode="JN" term="%229709118%22">Oral oncology</searchLink> [Oral Oncol] 2026 Jul; Vol. 178, pp. 108004. <i>Date of Electronic Publication: </i>2026 May 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9709118 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0593 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213688375%22">13688375 </searchLink><i>NLM ISO Abbreviation: </i>Oral Oncol <i>Subsets: </i>MEDLINE
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