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Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study.

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Title: Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study.
Authors: Patel M; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., Feng W; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Mckay NS; Department of Radiology, Washington University School of Medicine, St Louis, MO, USA., Millar PR; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Liu M; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., Yang C; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., Cetin A; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., Johnson M; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., Budde J; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., Western D; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., Marsh TW; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., Saliu IO; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Gordon BA; Department of Radiology, Washington University School of Medicine, St Louis, MO, USA., Guerra JJL; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Morris JC; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO, USA., Bateman RJ; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., McDade E; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Holtzman DM; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO, USA., Ryan NS; Dementia Research Center and UK Dementia Research Institute, University College London Queen Square Institute of Neurology, London, UK., Benzinger TLS; Department of Radiology, Washington University School of Medicine, St Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA., Renton AE; Ronald M Loeb Center for Alzheimer's Disease, Department of Genetics and Genomic Sciences, and Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Goate AM; Ronald M Loeb Center for Alzheimer's Disease, Department of Genetics and Genomic Sciences, and Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ibanez L; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA., Sung YJ; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA; Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA., Zhao G; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO, USA., Pottier C; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA. Electronic address: cpottier@wustl.edu.
Corporate Authors: Dominantly Inherited Alzheimer Network
Source: The Lancet. Neurology [Lancet Neurol] 2026 Jun; Vol. 25 (6), pp. 581-590.
Publication Type: Journal Article
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 101139309 Publication Model: Print Cited Medium: Internet ISSN: 1474-4465 (Electronic) Linking ISSN: 14744422 NLM ISO Abbreviation: Lancet Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Patel+M%22">Patel M</searchLink>; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Feng+W%22">Feng W</searchLink>; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Mckay+NS%22">Mckay NS</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Millar+PR%22">Millar PR</searchLink>; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Cetin+A%22">Cetin A</searchLink>; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+M%22">Johnson M</searchLink>; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Budde+J%22">Budde J</searchLink>; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Western+D%22">Western D</searchLink>; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Marsh+TW%22">Marsh TW</searchLink>; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Saliu+IO%22">Saliu IO</searchLink>; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Gordon+BA%22">Gordon BA</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Guerra+JJL%22">Guerra JJL</searchLink>; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Morris+JC%22">Morris JC</searchLink>; 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Dementia Research Center and UK Dementia Research Institute, University College London Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Benzinger+TLS%22">Benzinger TLS</searchLink>; Department of Radiology, Washington University School of Medicine, St Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Renton+AE%22">Renton AE</searchLink>; Ronald M Loeb Center for Alzheimer's Disease, Department of Genetics and Genomic Sciences, and Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Goate+AM%22">Goate AM</searchLink>; Ronald M Loeb Center for Alzheimer's Disease, Department of Genetics and Genomic Sciences, and Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ibanez+L%22">Ibanez L</searchLink>; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Sung+YJ%22">Sung YJ</searchLink>; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA; Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+G%22">Zhao G</searchLink>; Department of Genetics, Washington University School of Medicine, St Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Pottier+C%22">Pottier C</searchLink>; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA; Neurogenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA. Electronic address: cpottier@wustl.edu.
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