VGLL3-Rearranged Spindle Cell Rhabdomyoblastic Tumor: A Clinicopathologic and Molecular Genetic Study of 18 Cases With Consistently Indolent Behavior.

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Title: VGLL3-Rearranged Spindle Cell Rhabdomyoblastic Tumor: A Clinicopathologic and Molecular Genetic Study of 18 Cases With Consistently Indolent Behavior.
Authors: Baranov E; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania., Ameline B; Bone Tumor Reference Center at the Institute of Medical Genetics and Pathology, University Hospital, University of Basel, Basel, Switzerland., Berthold R; Gerhard-Domagk-Institute of Pathology, Münster University Hospital, Münster, Germany., Perry KD; Department of Pathology, University of Michigan, Ann Arbor, Michigan., Torres-Mora J; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota., Maclean F; Douglass Hanly Moir Pathology, Sydney, Australia; Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Abrahao-Machado LF; Bacchi Laboratory, Botucatu, Sao Paulo, Brazil., Michal M; Biopticka Laboratory, Ltd, Plzen, Czech Republic; Department of Pathology, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic., Kerr DA; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, New Hampshire., Lu L; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, New Hampshire., Hou T; Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana., Malik F; Department of Pathology, St. Jude's Children's Research Hospital, Memphis, Tennessee., Goldfaden JS; Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania., Prasad JL; Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania., Gestrich C; Department of Pathology, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Stelow E; University of Virginia, Charlottesville, Virginia., Fanburg-Smith JC; University of Virginia, Charlottesville, Virginia., LeGallo R; University of Virginia, Charlottesville, Virginia., Zadeh S; University of Virginia, Charlottesville, Virginia., Haglund de Flon F; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Zhang PJ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania., Hartmann W; Gerhard-Domagk-Institute of Pathology, Münster University Hospital, Münster, Germany., Miele E; Onco-Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome., Stejskal V; The Fingerland Department of Pathology, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Hradec Králove, Czech Republic., Alaggio R; Pathology Unit, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy., Agaimy A; Institute of Pathology, University Hospital Erlangen (UKER), Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany., Nielsen GP; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Demicco EG; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Baumhoer D; Bone Tumor Reference Center at the Institute of Medical Genetics and Pathology, University Hospital, University of Basel, Basel, Switzerland; Basel Research Center for Child Health (BRCCH), Basel, Switzerland; HOCH Health Ostschweiz, Institute of Pathology, Reference Center for Bone and Craniofacial Tumors, St Gallen, Switzerland., Dehner CA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: carina.dehner@pennmedicine.upenn.edu.
Source: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 2026 Jul; Vol. 39 (7), pp. 101014. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 8806605 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0285 (Electronic) Linking ISSN: 08933952 NLM ISO Abbreviation: Mod Pathol Subsets: MEDLINE
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  Data: VGLL3-Rearranged Spindle Cell Rhabdomyoblastic Tumor: A Clinicopathologic and Molecular Genetic Study of 18 Cases With Consistently Indolent Behavior.
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  Data: <searchLink fieldCode="AU" term="%22Baranov+E%22">Baranov E</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Ameline+B%22">Ameline B</searchLink>; Bone Tumor Reference Center at the Institute of Medical Genetics and Pathology, University Hospital, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Berthold+R%22">Berthold R</searchLink>; Gerhard-Domagk-Institute of Pathology, Münster University Hospital, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Perry+KD%22">Perry KD</searchLink>; Department of Pathology, University of Michigan, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Torres-Mora+J%22">Torres-Mora J</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Maclean+F%22">Maclean F</searchLink>; Douglass Hanly Moir Pathology, Sydney, Australia; Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Abrahao-Machado+LF%22">Abrahao-Machado LF</searchLink>; Bacchi Laboratory, Botucatu, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Michal+M%22">Michal M</searchLink>; Biopticka Laboratory, Ltd, Plzen, Czech Republic; Department of Pathology, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kerr+DA%22">Kerr DA</searchLink>; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, New Hampshire.<br /><searchLink fieldCode="AU" term="%22Lu+L%22">Lu L</searchLink>; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, New Hampshire.<br /><searchLink fieldCode="AU" term="%22Hou+T%22">Hou T</searchLink>; Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Malik+F%22">Malik F</searchLink>; Department of Pathology, St. Jude's Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Goldfaden+JS%22">Goldfaden JS</searchLink>; Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Prasad+JL%22">Prasad JL</searchLink>; Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Gestrich+C%22">Gestrich C</searchLink>; Department of Pathology, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Stelow+E%22">Stelow E</searchLink>; University of Virginia, Charlottesville, Virginia.<br /><searchLink fieldCode="AU" term="%22Fanburg-Smith+JC%22">Fanburg-Smith JC</searchLink>; University of Virginia, Charlottesville, Virginia.<br /><searchLink fieldCode="AU" term="%22LeGallo+R%22">LeGallo R</searchLink>; University of Virginia, Charlottesville, Virginia.<br /><searchLink fieldCode="AU" term="%22Zadeh+S%22">Zadeh S</searchLink>; University of Virginia, Charlottesville, Virginia.<br /><searchLink fieldCode="AU" term="%22Haglund+de+Flon+F%22">Haglund de Flon F</searchLink>; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Zhang+PJ%22">Zhang PJ</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Hartmann+W%22">Hartmann W</searchLink>; Gerhard-Domagk-Institute of Pathology, Münster University Hospital, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Miele+E%22">Miele E</searchLink>; Onco-Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome.<br /><searchLink fieldCode="AU" term="%22Stejskal+V%22">Stejskal V</searchLink>; The Fingerland Department of Pathology, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Hradec Králove, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Alaggio+R%22">Alaggio R</searchLink>; Pathology Unit, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Agaimy+A%22">Agaimy A</searchLink>; Institute of Pathology, University Hospital Erlangen (UKER), Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Nielsen+GP%22">Nielsen GP</searchLink>; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Demicco+EG%22">Demicco EG</searchLink>; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Baumhoer+D%22">Baumhoer D</searchLink>; Bone Tumor Reference Center at the Institute of Medical Genetics and Pathology, University Hospital, University of Basel, Basel, Switzerland; Basel Research Center for Child Health (BRCCH), Basel, Switzerland; HOCH Health Ostschweiz, Institute of Pathology, Reference Center for Bone and Craniofacial Tumors, St Gallen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dehner+CA%22">Dehner CA</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: carina.dehner@pennmedicine.upenn.edu.
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