Therapeutic potential of nicorandil vs nebivolol in attenuating PKC/P38MAPK signaling via PPARγ/KLOTHO/CREB pathway signaling: molecular docking and experimental validation in rat model of unilateral ureteric obstruction.
Saved in:
| Title: | Therapeutic potential of nicorandil vs nebivolol in attenuating PKC/P38MAPK signaling via PPARγ/KLOTHO/CREB pathway signaling: molecular docking and experimental validation in rat model of unilateral ureteric obstruction. |
|---|---|
| Authors: | Khalifa AK; Department of Medical Pharmacology, Faculty of Medicine, Cairo University, El-Manial, Cairo, 11562, Egypt; Department of Medical Pharmacology, Faculty of Medicine, Nahda University, Beni Suef, 62521, Egypt. Electronic address: amirakaramkhalifa@cu.edu.eg., Galal AM; Department of Medical Pharmacology, Faculty of Medicine, Cairo University, El-Manial, Cairo, 11562, Egypt. Electronic address: amrmaher@kasralainy.edu.eg., Saber S; Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt. Electronic address: sameh.saber@deltauniv.edu.eg., El-Sayed AF; Microbial Genetics Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt. Electronic address: ahmedfikry.nrc@gmail.com., Alsibaee AM; Department of pharmacognosy and pharmaceutical chemistry, College of pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: Asibaee@taibahu.edu.sa., Saeedi T; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: Tahsaedi@taibahu.edu.sa., Alsubhi S; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: smssubhi@taibahu.edu.sa., Miski SF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: Smiski@taibahu.edu.sa., Aboulhoda BE; Department of Medical Anatomy and Embryology, Faculty of Medicine, Cairo University, El- Manial, Cairo, Egypt. Electronic address: basma.emad@kasralainy.edu.eg., Mohamed EEE; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, El- Manial, Cairo, Egypt. Electronic address: eman.emadeldin@kasralainy.edu.eg., Wanas H; Department of Medical Pharmacology, Faculty of Medicine, Cairo University, El-Manial, Cairo, 11562, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: Hanaa.wanas@karalainy.edu.eg. |
| Source: | European journal of pharmacology [Eur J Pharmacol] 2026 Jun 15; Vol. 1027, pp. 178962. Date of Electronic Publication: 2026 May 13. |
| Publication Type: | Journal Article; Comparative Study |
| Journal Info: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42128192 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Therapeutic potential of nicorandil vs nebivolol in attenuating PKC/P38MAPK signaling via PPARγ/KLOTHO/CREB pathway signaling: molecular docking and experimental validation in rat model of unilateral ureteric obstruction. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Khalifa+AK%22">Khalifa AK</searchLink>; Department of Medical Pharmacology, Faculty of Medicine, Cairo University, El-Manial, Cairo, 11562, Egypt; Department of Medical Pharmacology, Faculty of Medicine, Nahda University, Beni Suef, 62521, Egypt. Electronic address: amirakaramkhalifa@cu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Galal+AM%22">Galal AM</searchLink>; Department of Medical Pharmacology, Faculty of Medicine, Cairo University, El-Manial, Cairo, 11562, Egypt. Electronic address: amrmaher@kasralainy.edu.eg.<br /><searchLink fieldCode="AU" term="%22Saber+S%22">Saber S</searchLink>; Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt. Electronic address: sameh.saber@deltauniv.edu.eg.<br /><searchLink fieldCode="AU" term="%22El-Sayed+AF%22">El-Sayed AF</searchLink>; Microbial Genetics Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt; Egypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt. Electronic address: ahmedfikry.nrc@gmail.com.<br /><searchLink fieldCode="AU" term="%22Alsibaee+AM%22">Alsibaee AM</searchLink>; Department of pharmacognosy and pharmaceutical chemistry, College of pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: Asibaee@taibahu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Saeedi+T%22">Saeedi T</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: Tahsaedi@taibahu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Alsubhi+S%22">Alsubhi S</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: smssubhi@taibahu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Miski+SF%22">Miski SF</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: Smiski@taibahu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Aboulhoda+BE%22">Aboulhoda BE</searchLink>; Department of Medical Anatomy and Embryology, Faculty of Medicine, Cairo University, El- Manial, Cairo, Egypt. Electronic address: basma.emad@kasralainy.edu.eg.<br /><searchLink fieldCode="AU" term="%22Mohamed+EEE%22">Mohamed EEE</searchLink>; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, El- Manial, Cairo, Egypt. Electronic address: eman.emadeldin@kasralainy.edu.eg.<br /><searchLink fieldCode="AU" term="%22Wanas+H%22">Wanas H</searchLink>; Department of Medical Pharmacology, Faculty of Medicine, Cairo University, El-Manial, Cairo, 11562, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia. Electronic address: Hanaa.wanas@karalainy.edu.eg. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%221254354%22">European journal of pharmacology</searchLink> [Eur J Pharmacol] 2026 Jun 15; Vol. 1027, pp. 178962. <i>Date of Electronic Publication: </i>2026 May 13. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Comparative Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>1254354 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0712 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200142999%22">00142999 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Pharmacol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42128192 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ejphar.2026.178962 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 178962 Titles: – TitleFull: Therapeutic potential of nicorandil vs nebivolol in attenuating PKC/P38MAPK signaling via PPARγ/KLOTHO/CREB pathway signaling: molecular docking and experimental validation in rat model of unilateral ureteric obstruction. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Khalifa AK – PersonEntity: Name: NameFull: Galal AM – PersonEntity: Name: NameFull: Saber S – PersonEntity: Name: NameFull: El-Sayed AF – PersonEntity: Name: NameFull: Alsibaee AM – PersonEntity: Name: NameFull: Saeedi T – PersonEntity: Name: NameFull: Alsubhi S – PersonEntity: Name: NameFull: Miski SF – PersonEntity: Name: NameFull: Aboulhoda BE – PersonEntity: Name: NameFull: Mohamed EEE – PersonEntity: Name: NameFull: Wanas H IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 06 Text: 2026 Jun 15 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1879-0712 Numbering: – Type: volume Value: 1027 Titles: – TitleFull: European journal of pharmacology Type: main |
| ResultId | 1 |
