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Cilostazol mitigates amiodarone-induced pulmonary toxicity and fibrosis by regulating the cAMP/TGF-β1 pathway-mediated epithelial-to-mesenchymal transition in rats.

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Title: Cilostazol mitigates amiodarone-induced pulmonary toxicity and fibrosis by regulating the cAMP/TGF-β1 pathway-mediated epithelial-to-mesenchymal transition in rats.
Authors: El-Gammal MA; Pharmacology and Biochemistry Department (Pharmacology), Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, Egypt., Yousef EH; Pharmacology and Biochemistry Department (Biochemistry), Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, Egypt. Ehamdy@horus.edu.eg., Abd Elhameed AG; Pharmacology and Biochemistry Department (Pharmacology), Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, Egypt. Ahmed_Gamal_Helal@mans.edu.eg.; Pharmacology and Toxicology Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Ahmed_Gamal_Helal@mans.edu.eg., Salama MM; Biochemistry Department, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt., Salahuddin MM; Pharmacology and Biochemistry Department (Biochemistry), Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, Egypt.
Source: Scientific reports [Sci Rep] 2026 May 13; Vol. 16 (1). Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Cilostazol mitigates amiodarone-induced pulmonary toxicity and fibrosis by regulating the cAMP/TGF-β1 pathway-mediated epithelial-to-mesenchymal transition in rats.
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  Data: <searchLink fieldCode="AU" term="%22El-Gammal+MA%22">El-Gammal MA</searchLink>; Pharmacology and Biochemistry Department (Pharmacology), Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, Egypt.<br /><searchLink fieldCode="AU" term="%22Yousef+EH%22">Yousef EH</searchLink>; Pharmacology and Biochemistry Department (Biochemistry), Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, Egypt. Ehamdy@horus.edu.eg.<br /><searchLink fieldCode="AU" term="%22Abd+Elhameed+AG%22">Abd Elhameed AG</searchLink>; Pharmacology and Biochemistry Department (Pharmacology), Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, Egypt. Ahmed_Gamal_Helal@mans.edu.eg.; Pharmacology and Toxicology Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Ahmed_Gamal_Helal@mans.edu.eg.<br /><searchLink fieldCode="AU" term="%22Salama+MM%22">Salama MM</searchLink>; Biochemistry Department, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt.<br /><searchLink fieldCode="AU" term="%22Salahuddin+MM%22">Salahuddin MM</searchLink>; Pharmacology and Biochemistry Department (Biochemistry), Faculty of Pharmacy, Horus University-Egypt, New Damietta, 34518, Egypt.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 May 13; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 May 13.
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        Value: 10.1038/s41598-026-45341-3
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