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The landscape of cocaine cytotoxicity and the role of sigma-1 receptor modulation and adulterant synergism.

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Title: The landscape of cocaine cytotoxicity and the role of sigma-1 receptor modulation and adulterant synergism.
Authors: Steinmetz A; Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.; Laboratory of Genetic Toxicology, Federal University of Health Sciences of Porto Alegre, Sarmento Leite 245, Sala 714, Prédio 3, Centro Histórico, Porto Alegre, RS, 90050-170, Brazil., Moro CF; Laboratory of Genetic Toxicology, Federal University of Health Sciences of Porto Alegre, Sarmento Leite 245, Sala 714, Prédio 3, Centro Histórico, Porto Alegre, RS, 90050-170, Brazil.; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil., Freese L; Laboratory of Neuropharmacology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil., de Abreu MS; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil., Braum RL; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil., Barros HMT; Laboratory of Neuropharmacology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil., Moura DJ; Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil. dinaram@ufcspa.edu.br.; Laboratory of Genetic Toxicology, Federal University of Health Sciences of Porto Alegre, Sarmento Leite 245, Sala 714, Prédio 3, Centro Histórico, Porto Alegre, RS, 90050-170, Brazil. dinaram@ufcspa.edu.br.; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil. dinaram@ufcspa.edu.br.
Source: Archives of toxicology [Arch Toxicol] 2026 Aug; Vol. 100 (8), pp. 3255-3263. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The landscape of cocaine cytotoxicity and the role of sigma-1 receptor modulation and adulterant synergism.
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  Data: <searchLink fieldCode="AU" term="%22Steinmetz+A%22">Steinmetz A</searchLink>; Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.; Laboratory of Genetic Toxicology, Federal University of Health Sciences of Porto Alegre, Sarmento Leite 245, Sala 714, Prédio 3, Centro Histórico, Porto Alegre, RS, 90050-170, Brazil.<br /><searchLink fieldCode="AU" term="%22Moro+CF%22">Moro CF</searchLink>; Laboratory of Genetic Toxicology, Federal University of Health Sciences of Porto Alegre, Sarmento Leite 245, Sala 714, Prédio 3, Centro Histórico, Porto Alegre, RS, 90050-170, Brazil.; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Freese+L%22">Freese L</searchLink>; Laboratory of Neuropharmacology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Abreu+MS%22">de Abreu MS</searchLink>; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Braum+RL%22">Braum RL</searchLink>; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Barros+HMT%22">Barros HMT</searchLink>; Laboratory of Neuropharmacology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Moura+DJ%22">Moura DJ</searchLink>; Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil. dinaram@ufcspa.edu.br.; Laboratory of Genetic Toxicology, Federal University of Health Sciences of Porto Alegre, Sarmento Leite 245, Sala 714, Prédio 3, Centro Histórico, Porto Alegre, RS, 90050-170, Brazil. dinaram@ufcspa.edu.br.; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil. dinaram@ufcspa.edu.br.
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  Data: <searchLink fieldCode="JN" term="%220417615%22">Archives of toxicology</searchLink> [Arch Toxicol] 2026 Aug; Vol. 100 (8), pp. 3255-3263. <i>Date of Electronic Publication: </i>2026 May 13.
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        Value: 10.1007/s00204-026-04434-8
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              Text: 2026 Aug
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