Decoding the role of chromatin context in the off-target effects of CRISPR gene editing with EGOLD.
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| Title: | Decoding the role of chromatin context in the off-target effects of CRISPR gene editing with EGOLD. |
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| Authors: | Feng H; State Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Gene Editing Technologies (Hainan), Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Guangdong, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, China., Zheng J; State Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Gene Editing Technologies (Hainan), Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Guangdong, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, China.; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning, Guangxi, China., Li N; State Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Gene Editing Technologies (Hainan), Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Guangdong, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, China.; Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei, China., Xie L; State Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Gene Editing Technologies (Hainan), Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Guangdong, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, China., Zuo E; State Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Gene Editing Technologies (Hainan), Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Guangdong, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, China. zuoerwei@caas.cn. |
| Source: | Cell discovery [Cell Discov] 2026 May 13; Vol. 12 (1). Date of Electronic Publication: 2026 May 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101661034 Publication Model: Electronic Cited Medium: Print ISSN: 2056-5968 (Print) Linking ISSN: 20565968 NLM ISO Abbreviation: Cell Discov Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2056-5968 |
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| DOI: | 10.1038/s41421-026-00889-2 |
