Grin2a knockout in adolescent dopamine neurons disrupts prediction error signaling and produces a phenotype relevant to schizophrenia.

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Title: Grin2a knockout in adolescent dopamine neurons disrupts prediction error signaling and produces a phenotype relevant to schizophrenia.
Authors: Kielhold ML; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA., Jacobs DS; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA., Torrado Pacheco A; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA., Lefner MJ; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA., Bogachuk AP; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA., Lebowitz JJ; Vollum Institute, Oregon Health & Science University, Portland, OR, USA., Langdon AJ; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA., Williams JT; Vollum Institute, Oregon Health & Science University, Portland, OR, USA., Zweifel LS; Department of Pharmacology, University of Washington, Seattle, WA, USA., Moghaddam B; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA. bita@ohsu.edu.
Source: Molecular psychiatry [Mol Psychiatry] 2026 May 13. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Kielhold+ML%22">Kielhold ML</searchLink>; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Jacobs+DS%22">Jacobs DS</searchLink>; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Torrado+Pacheco+A%22">Torrado Pacheco A</searchLink>; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Lefner+MJ%22">Lefner MJ</searchLink>; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Bogachuk+AP%22">Bogachuk AP</searchLink>; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Lebowitz+JJ%22">Lebowitz JJ</searchLink>; Vollum Institute, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Langdon+AJ%22">Langdon AJ</searchLink>; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Williams+JT%22">Williams JT</searchLink>; Vollum Institute, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Zweifel+LS%22">Zweifel LS</searchLink>; Department of Pharmacology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Moghaddam+B%22">Moghaddam B</searchLink>; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA. bita@ohsu.edu.
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        Value: 10.1038/s41380-026-03632-1
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              Text: 2026 May 13
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