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Sleep chart of biological ageing clocks in middle and late life.

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Title: Sleep chart of biological ageing clocks in middle and late life.
Authors: O'Toole CK; Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA., Song Z; Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA., Anagnostakis F; Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA., Yang Z; Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA., Tian YE; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia., Duggan MR; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Zou C; Department of Radiology, Columbia University, New York, NY, USA., Leng Y; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA., Cai Y; Department of Otolaryngology, Head and Neck Surgery, Columbia University, New York, NY, USA., Bai W; Department of Brain Sciences, Imperial College London, London, UK.; Department of Computing, Imperial College London, London, UK., Fu CHY; School of Psychology, University of East London, London, UK.; Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR), Maudsley Biomedical Research Center (BRC), London, UK., Rafii MS; Alzheimer's Therapeutic Research Institute, Keck School of Medicine of the University of Southern California, San Diego, CA, USA., Aisen P; Alzheimer's Therapeutic Research Institute, Keck School of Medicine of the University of Southern California, San Diego, CA, USA., Wang G; Department of Neurology, Columbia University, New York, NY, USA., De Jager PL; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Zeng J; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Oh HS; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Brain and Body Research Center of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zhou X; Department of Computer Science, Columbia University, New York, NY, USA., Walker KA; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Belsky DW; Robert N. Butler Columbia Aging Center and Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA., Zalesky A; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia., Simonsick EM; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA., Resnick SM; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Ferrucci L; National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Davatzikos C; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wen J; Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA. junhao.wen89@gmail.com.; Department of Radiology, Columbia University, New York, NY, USA. junhao.wen89@gmail.com.; Department of Computer Science, Columbia University, New York, NY, USA. junhao.wen89@gmail.com.; Department of Biomedical Engineering, Columbia University, New York, NY, USA. junhao.wen89@gmail.com.; New York Genome Center (NYGC), New York, NY, USA. junhao.wen89@gmail.com.
Corporate Authors: MULTI Consortium
Source: Nature [Nature] 2026 May 13. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22O'Toole+CK%22">O'Toole CK</searchLink>; Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Song+Z%22">Song Z</searchLink>; Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Anagnostakis+F%22">Anagnostakis F</searchLink>; Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tian+YE%22">Tian YE</searchLink>; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Duggan+MR%22">Duggan MR</searchLink>; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Zou+C%22">Zou C</searchLink>; Department of Radiology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Leng+Y%22">Leng Y</searchLink>; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Department of Otolaryngology, Head and Neck Surgery, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bai+W%22">Bai W</searchLink>; Department of Brain Sciences, Imperial College London, London, UK.; Department of Computing, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Fu+CHY%22">Fu CHY</searchLink>; School of Psychology, University of East London, London, UK.; Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; National Institute for Health and Care Research (NIHR), Maudsley Biomedical Research Center (BRC), London, UK.<br /><searchLink fieldCode="AU" term="%22Rafii+MS%22">Rafii MS</searchLink>; Alzheimer's Therapeutic Research Institute, Keck School of Medicine of the University of Southern California, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Aisen+P%22">Aisen P</searchLink>; Alzheimer's Therapeutic Research Institute, Keck School of Medicine of the University of Southern California, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; Department of Neurology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22De+Jager+PL%22">De Jager PL</searchLink>; Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zeng+J%22">Zeng J</searchLink>; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Oh+HS%22">Oh HS</searchLink>; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Brain and Body Research Center of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Department of Computer Science, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Walker+KA%22">Walker KA</searchLink>; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Belsky+DW%22">Belsky DW</searchLink>; Robert N. Butler Columbia Aging Center and Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zalesky+A%22">Zalesky A</searchLink>; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Simonsick+EM%22">Simonsick EM</searchLink>; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Resnick+SM%22">Resnick SM</searchLink>; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ferrucci+L%22">Ferrucci L</searchLink>; National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Davatzikos+C%22">Davatzikos C</searchLink>; Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Center for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wen+J%22">Wen J</searchLink>; Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA. junhao.wen89@gmail.com.; Department of Radiology, Columbia University, New York, NY, USA. junhao.wen89@gmail.com.; Department of Computer Science, Columbia University, New York, NY, USA. junhao.wen89@gmail.com.; Department of Biomedical Engineering, Columbia University, New York, NY, USA. junhao.wen89@gmail.com.; New York Genome Center (NYGC), New York, NY, USA. junhao.wen89@gmail.com.
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