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Asymmetric nanozymes improve cardiac purine catabolism and alleviate oxidative stress of myocardium to treat ischemic heart disease.

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Title: Asymmetric nanozymes improve cardiac purine catabolism and alleviate oxidative stress of myocardium to treat ischemic heart disease.
Authors: Jiang Y; Department of Burn and Plastic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226000, China., Chen H; Institute of Geriatrics, School of Life Sciences, Shanghai University, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai University, Nantong, 226011, China.; Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, 200444, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China., Chen W; Department of Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China., Zhu L; Institute of Geriatrics, School of Life Sciences, Shanghai University, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai University, Nantong, 226011, China.; Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, 200444, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China., Wang X; School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, 200093, China., Sun P; Institute of Geriatrics, School of Life Sciences, Shanghai University, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai University, Nantong, 226011, China.; Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, 200444, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China., Su C; Department of Cardiology, Heart Center of Fujian Province, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian, China., Gui R; Institute of Geriatrics, School of Life Sciences, Shanghai University, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai University, Nantong, 226011, China.; Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, 200444, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China., Yang H; School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, 200444, China.; Shanghai Key Laboratory of Intelligent Manufacturing and Robotics, Shanghai University, Shanghai, 200444, China.; Shanghai Institute of Intelligent Science and Technology, Tongji University, Shanghai, China., Yue T; School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, 200444, China.; Shanghai Key Laboratory of Intelligent Manufacturing and Robotics, Shanghai University, Shanghai, 200444, China.; Shanghai Institute of Intelligent Science and Technology, Tongji University, Shanghai, China., Wang K; School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, 200444, China.; Key Laboratory of Advanced Display and System Application, Ministry of Education, Shanghai University, Shanghai, 200444, China.; State Key Laboratory of Tribology in Advanced Equipment, Tsinghua University, Beijing, 100084, China., Yang P; School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, 200093, China., Dou L; School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, 200093, China., Zhao L; Department of Neurology, Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China., Chatterjee E; Cardiovascular Division of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Li G; Cardiovascular Division of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Chen X; Institute of Geriatrics, School of Life Sciences, Shanghai University, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai University, Nantong, 226011, China. chenxuerui@shu.edu.cn.; Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, 200444, China. chenxuerui@shu.edu.cn.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China. chenxuerui@shu.edu.cn., Chen J; Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China. jsshcjl@ntu.edu.cn.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 May 13; Vol. 24 (1). Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Asymmetric nanozymes improve cardiac purine catabolism and alleviate oxidative stress of myocardium to treat ischemic heart disease.
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  Data: <searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; Department of Burn and Plastic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226000, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Institute of Geriatrics, School of Life Sciences, Shanghai University, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai University, Nantong, 226011, China.; Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, 200444, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.<br /><searchLink fieldCode="AU" term="%22Zhu+L%22">Zhu L</searchLink>; Institute of Geriatrics, School of Life Sciences, Shanghai University, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai University, Nantong, 226011, China.; Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, 200444, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, 200093, China.<br /><searchLink fieldCode="AU" term="%22Sun+P%22">Sun P</searchLink>; Institute of Geriatrics, School of Life Sciences, Shanghai University, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai University, Nantong, 226011, China.; Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, 200444, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.<br /><searchLink fieldCode="AU" term="%22Su+C%22">Su C</searchLink>; Department of Cardiology, Heart Center of Fujian Province, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Gui+R%22">Gui R</searchLink>; Institute of Geriatrics, School of Life Sciences, Shanghai University, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai University, Nantong, 226011, China.; Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, 200444, China.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, 200444, China.; Shanghai Key Laboratory of Intelligent Manufacturing and Robotics, Shanghai University, Shanghai, 200444, China.; Shanghai Institute of Intelligent Science and Technology, Tongji University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yue+T%22">Yue T</searchLink>; School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, 200444, China.; Shanghai Key Laboratory of Intelligent Manufacturing and Robotics, Shanghai University, Shanghai, 200444, China.; Shanghai Institute of Intelligent Science and Technology, Tongji University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+K%22">Wang K</searchLink>; School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, 200444, China.; Key Laboratory of Advanced Display and System Application, Ministry of Education, Shanghai University, Shanghai, 200444, China.; State Key Laboratory of Tribology in Advanced Equipment, Tsinghua University, Beijing, 100084, China.<br /><searchLink fieldCode="AU" term="%22Yang+P%22">Yang P</searchLink>; School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, 200093, China.<br /><searchLink fieldCode="AU" term="%22Dou+L%22">Dou L</searchLink>; School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, 200093, China.<br /><searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; Department of Neurology, Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China.<br /><searchLink fieldCode="AU" term="%22Chatterjee+E%22">Chatterjee E</searchLink>; Cardiovascular Division of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Cardiovascular Division of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Institute of Geriatrics, School of Life Sciences, Shanghai University, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai University, Nantong, 226011, China. chenxuerui@shu.edu.cn.; Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, 200444, China. chenxuerui@shu.edu.cn.; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China. chenxuerui@shu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China. jsshcjl@ntu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101152208%22">Journal of nanobiotechnology</searchLink> [J Nanobiotechnology] 2026 May 13; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 May 13.
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