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Intrapulmonary penetration of ceftolozane/tazobactam and ceftazidime/avibactam administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial.

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Title: Intrapulmonary penetration of ceftolozane/tazobactam and ceftazidime/avibactam administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial.
Authors: Benítez-Cano A; Department of Anaesthesiology and Surgical Intensive Care, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.; Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain., Sancho-Araiz A; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug ResearchLeiden University, Leiden, The Netherlands., Carazo J; Department of Anaesthesiology and Surgical Intensive Care, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain., Ramos I; Department of Anaesthesiology and Surgical Intensive Care, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain., Sánchez-Font A; Respiratory Medicine Department, Hospital del Mar-IMIM (Hospital del Mar Research Institute) and CIBER de Enfermedades Respiratorias (CIBERES), ISCIII, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain., Chalela R; Respiratory Medicine Department, Hospital del Mar-IMIM (Hospital del Mar Research Institute) and CIBER de Enfermedades Respiratorias (CIBERES), ISCIII, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain., López-Palacio M; Laboratory Department, Laboratori de Referència de Catalunya, Barcelona, Spain., García-Prieto FF; Laboratory Department, Laboratori de Referència de Catalunya, Barcelona, Spain., Navarrete-Rouco ME; Pharmacy Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain., Juanes-Borrego AM; Pharmacy Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain., Gómez-Junyent J; Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.; Infectious Diseases Department, Hospital del Mar, Barcelona, Spain.; CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain., Horcajada JP; Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.; Infectious Diseases Department, Hospital del Mar, Barcelona, Spain.; CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain., Adalia R; Department of Anaesthesiology and Surgical Intensive Care, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain., Roberts J; University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.; Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia., Sorlí L; Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain. lsorli@hmar.cat.; Universitat Pompeu Fabra, Barcelona, Spain. lsorli@hmar.cat.; Infectious Diseases Department, Hospital del Mar, Barcelona, Spain. lsorli@hmar.cat.; CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. lsorli@hmar.cat., Luque S; Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.; Pharmacy Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.; CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.
Source: Critical care (London, England) [Crit Care] 2026 May 13; Vol. 30 (1). Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Intrapulmonary penetration of ceftolozane/tazobactam and ceftazidime/avibactam administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial.
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  Data: <searchLink fieldCode="AU" term="%22Benítez-Cano+A%22">Benítez-Cano A</searchLink>; Department of Anaesthesiology and Surgical Intensive Care, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.; Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sancho-Araiz+A%22">Sancho-Araiz A</searchLink>; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug ResearchLeiden University, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Carazo+J%22">Carazo J</searchLink>; Department of Anaesthesiology and Surgical Intensive Care, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ramos+I%22">Ramos I</searchLink>; Department of Anaesthesiology and Surgical Intensive Care, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez-Font+A%22">Sánchez-Font A</searchLink>; Respiratory Medicine Department, Hospital del Mar-IMIM (Hospital del Mar Research Institute) and CIBER de Enfermedades Respiratorias (CIBERES), ISCIII, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Chalela+R%22">Chalela R</searchLink>; Respiratory Medicine Department, Hospital del Mar-IMIM (Hospital del Mar Research Institute) and CIBER de Enfermedades Respiratorias (CIBERES), ISCIII, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22López-Palacio+M%22">López-Palacio M</searchLink>; Laboratory Department, Laboratori de Referència de Catalunya, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22García-Prieto+FF%22">García-Prieto FF</searchLink>; Laboratory Department, Laboratori de Referència de Catalunya, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Navarrete-Rouco+ME%22">Navarrete-Rouco ME</searchLink>; Pharmacy Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Juanes-Borrego+AM%22">Juanes-Borrego AM</searchLink>; Pharmacy Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Gómez-Junyent+J%22">Gómez-Junyent J</searchLink>; Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.; Infectious Diseases Department, Hospital del Mar, Barcelona, Spain.; CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Horcajada+JP%22">Horcajada JP</searchLink>; Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.; Infectious Diseases Department, Hospital del Mar, Barcelona, Spain.; CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Adalia+R%22">Adalia R</searchLink>; Department of Anaesthesiology and Surgical Intensive Care, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Roberts+J%22">Roberts J</searchLink>; University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.; Departments of Pharmacy and Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Sorlí+L%22">Sorlí L</searchLink>; Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain. lsorli@hmar.cat.; Universitat Pompeu Fabra, Barcelona, Spain. lsorli@hmar.cat.; Infectious Diseases Department, Hospital del Mar, Barcelona, Spain. lsorli@hmar.cat.; CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. lsorli@hmar.cat.<br /><searchLink fieldCode="AU" term="%22Luque+S%22">Luque S</searchLink>; Infectious Pathology and Antimicrobials Research Group (IPAR), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.; Pharmacy Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.; CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.
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  Data: <searchLink fieldCode="JN" term="%229801902%22">Critical care (London, England)</searchLink> [Crit Care] 2026 May 13; Vol. 30 (1). <i>Date of Electronic Publication: </i>2026 May 13.
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