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Examining predictors of scale-up penalty in preliminary studies of health behavior interventions and subsequent larger trials: a meta-epidemiological review of diverse fields.

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Title: Examining predictors of scale-up penalty in preliminary studies of health behavior interventions and subsequent larger trials: a meta-epidemiological review of diverse fields.
Authors: von Klinggraeff L; Department of Community and Behavioral Health Sciences, School of Public Health, Augusta University, 2500 Walton Way, Augusta, GA, 30904, USA. lvonklinggraeff@augusta.edu., Pfledderer CD; School of Public Health in Austin, The University of Texas Health Science Center Houston, 1836 San Jacinto Blvd, Austin, TX, 78701, USA., Burkart S; Department of Exercise Science, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA., Ramey K; Department of Exercise Science, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA., Smith M; Department of Exercise Science, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA., McLain AC; Arnold School of Public Health, Department of Epidemiology and Biostatistics, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA., Armstrong B; Department of Exercise Science, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA., Weaver RG; Department of Exercise Science, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA., Okely A; School of Health and Society, University of Wollongong, Northfields Ave, Wollongong, New South Wales, 2500, Australia.; Department of Sport, Food, and Natural Sciences, Western Norway University, Røyrgata 6, 6856, Sogndal, Norway., Lubans D; Centre for Active Living and Learning, University of Newcastle, University Dr, Callaghan, New South Wales, 2308, Australia.; Hunter Medical Research Institute, Lot 1 Kookaburra Cct, New Lambton Heights, New South Wales, 2305, Australia.; Faculty of Sport and Health Sciences, University of Jyväskylä, Seminaarinkatu 15, 40014, Jyväskylä, Finland., Ioannidis JPA; Departments of Medicine, of Epidemiology and Population Health, of Biomedical Data Science, and of Statistics, and Meta-Research Innovation Center at Stanford (METRICS), Stanford University, 300 Pasteur Drive Stanford, Stanford, CA, 94305, USA., Jago R; Bristol Medical School, Population Health Sciences, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK., Turner-McGrievy G; Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, 921 Assembly Street, Columbia, SC 29208, USA., Thrasher J; Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, 921 Assembly Street, Columbia, SC 29208, USA., Li X; Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, 921 Assembly Street, Columbia, SC 29208, USA., Beets MW; Department of Exercise Science, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA.
Source: Pilot and feasibility studies [Pilot Feasibility Stud] 2026 May 13; Vol. 12 (1). Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101676536 Publication Model: Electronic Cited Medium: Print ISSN: 2055-5784 (Print) Linking ISSN: 20555784 NLM ISO Abbreviation: Pilot Feasibility Stud Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Examining predictors of scale-up penalty in preliminary studies of health behavior interventions and subsequent larger trials: a meta-epidemiological review of diverse fields.
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  Data: <searchLink fieldCode="AU" term="%22von+Klinggraeff+L%22">von Klinggraeff L</searchLink>; Department of Community and Behavioral Health Sciences, School of Public Health, Augusta University, 2500 Walton Way, Augusta, GA, 30904, USA. lvonklinggraeff@augusta.edu.<br /><searchLink fieldCode="AU" term="%22Pfledderer+CD%22">Pfledderer CD</searchLink>; School of Public Health in Austin, The University of Texas Health Science Center Houston, 1836 San Jacinto Blvd, Austin, TX, 78701, USA.<br /><searchLink fieldCode="AU" term="%22Burkart+S%22">Burkart S</searchLink>; Department of Exercise Science, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA.<br /><searchLink fieldCode="AU" term="%22Ramey+K%22">Ramey K</searchLink>; Department of Exercise Science, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA.<br /><searchLink fieldCode="AU" term="%22Smith+M%22">Smith M</searchLink>; Department of Exercise Science, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA.<br /><searchLink fieldCode="AU" term="%22McLain+AC%22">McLain AC</searchLink>; Arnold School of Public Health, Department of Epidemiology and Biostatistics, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA.<br /><searchLink fieldCode="AU" term="%22Armstrong+B%22">Armstrong B</searchLink>; Department of Exercise Science, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA.<br /><searchLink fieldCode="AU" term="%22Weaver+RG%22">Weaver RG</searchLink>; Department of Exercise Science, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA.<br /><searchLink fieldCode="AU" term="%22Okely+A%22">Okely A</searchLink>; School of Health and Society, University of Wollongong, Northfields Ave, Wollongong, New South Wales, 2500, Australia.; Department of Sport, Food, and Natural Sciences, Western Norway University, Røyrgata 6, 6856, Sogndal, Norway.<br /><searchLink fieldCode="AU" term="%22Lubans+D%22">Lubans D</searchLink>; Centre for Active Living and Learning, University of Newcastle, University Dr, Callaghan, New South Wales, 2308, Australia.; Hunter Medical Research Institute, Lot 1 Kookaburra Cct, New Lambton Heights, New South Wales, 2305, Australia.; Faculty of Sport and Health Sciences, University of Jyväskylä, Seminaarinkatu 15, 40014, Jyväskylä, Finland.<br /><searchLink fieldCode="AU" term="%22Ioannidis+JPA%22">Ioannidis JPA</searchLink>; Departments of Medicine, of Epidemiology and Population Health, of Biomedical Data Science, and of Statistics, and Meta-Research Innovation Center at Stanford (METRICS), Stanford University, 300 Pasteur Drive Stanford, Stanford, CA, 94305, USA.<br /><searchLink fieldCode="AU" term="%22Jago+R%22">Jago R</searchLink>; Bristol Medical School, Population Health Sciences, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.<br /><searchLink fieldCode="AU" term="%22Turner-McGrievy+G%22">Turner-McGrievy G</searchLink>; Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, 921 Assembly Street, Columbia, SC 29208, USA.<br /><searchLink fieldCode="AU" term="%22Thrasher+J%22">Thrasher J</searchLink>; Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, 921 Assembly Street, Columbia, SC 29208, USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, 921 Assembly Street, Columbia, SC 29208, USA.<br /><searchLink fieldCode="AU" term="%22Beets+MW%22">Beets MW</searchLink>; Department of Exercise Science, University of South Carolina, 921 Assembly Street, Columbia, SC, 29208, USA.
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  Data: <searchLink fieldCode="JN" term="%22101676536%22">Pilot and feasibility studies</searchLink> [Pilot Feasibility Stud] 2026 May 13; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 May 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101676536 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2055-5784 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220555784%22">20555784 </searchLink><i>NLM ISO Abbreviation: </i>Pilot Feasibility Stud <i>Subsets: </i>PubMed not MEDLINE
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        Text: English
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