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Improve genetic quality control to increase rigor and reproducibility of mouse research.

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Title: Improve genetic quality control to increase rigor and reproducibility of mouse research.
Authors: Pardo-Manuel de Villena F; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, School of Medicine, UNC-CH, Chapel Hill, NC, USA., Amos-Landgraf JM; MMRRC-MU, Department of Pathobiology and Integrative Biosciences, University of Missouri, Columbia, MO, USA., Bell TA; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA., Blanchard MW; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA., Brennan J; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA., Carlson C; MMRRC-ICSC (Informatics, Coordination and Service Center), Genome Center, University of California-Davis (UC-D), Davis, CA, USA., Ciavatta DJ; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.; UNC Kidney Center, School of Medicine, UNC-CH, Chapel Hill, NC, USA., Cotney PA; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA., Ferris MT; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA., Hock P; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA., Korf I; MMRRC-ICSC (Informatics, Coordination and Service Center), Genome Center, University of California-Davis (UC-D), Davis, CA, USA.; Department of Molecular and Cellular Biology, College of Biological Sciences, UC-D, Davis, CA, USA., Lloyd KCK; Department of Molecular and Cellular Biology, College of Biological Sciences, UC-D, Davis, CA, USA.; Department of Surgery, School of Medicine, UC-D, Sacramento, CA, USA.; MMRRC-UC Davis and Mouse Biology Program, UC-D, Davis, CA, USA., Lutz C; The Jackson Laboratory, Bar Harbor, ME, USA., Lynch RM; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA., Magnuson T; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, School of Medicine, UNC-CH, Chapel Hill, NC, USA., Murray SA; The Jackson Laboratory, Bar Harbor, ME, USA., Patel S; MMRRC-ICSC (Informatics, Coordination and Service Center), Genome Center, University of California-Davis (UC-D), Davis, CA, USA., Reinholdt LG; The Jackson Laboratory, Bar Harbor, ME, USA., Sigmon JS; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.; Department of Computer Science, UNC-CH, Chapel Hill, NC, USA., Willis B; MMRRC-UC Davis and Mouse Biology Program, UC-D, Davis, CA, USA., Xenakis JG; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.
Source: Science (New York, N.Y.) [Science] 2026 May 14; Vol. 392 (6799), pp. 698-700. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Improve genetic quality control to increase rigor and reproducibility of mouse research.
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  Data: <searchLink fieldCode="AU" term="%22Pardo-Manuel+de+Villena+F%22">Pardo-Manuel de Villena F</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, School of Medicine, UNC-CH, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Amos-Landgraf+JM%22">Amos-Landgraf JM</searchLink>; MMRRC-MU, Department of Pathobiology and Integrative Biosciences, University of Missouri, Columbia, MO, USA.<br /><searchLink fieldCode="AU" term="%22Bell+TA%22">Bell TA</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Blanchard+MW%22">Blanchard MW</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Brennan+J%22">Brennan J</searchLink>; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Carlson+C%22">Carlson C</searchLink>; MMRRC-ICSC (Informatics, Coordination and Service Center), Genome Center, University of California-Davis (UC-D), Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ciavatta+DJ%22">Ciavatta DJ</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.; UNC Kidney Center, School of Medicine, UNC-CH, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Cotney+PA%22">Cotney PA</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ferris+MT%22">Ferris MT</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hock+P%22">Hock P</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Korf+I%22">Korf I</searchLink>; MMRRC-ICSC (Informatics, Coordination and Service Center), Genome Center, University of California-Davis (UC-D), Davis, CA, USA.; Department of Molecular and Cellular Biology, College of Biological Sciences, UC-D, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lloyd+KCK%22">Lloyd KCK</searchLink>; Department of Molecular and Cellular Biology, College of Biological Sciences, UC-D, Davis, CA, USA.; Department of Surgery, School of Medicine, UC-D, Sacramento, CA, USA.; MMRRC-UC Davis and Mouse Biology Program, UC-D, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lutz+C%22">Lutz C</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA.<br /><searchLink fieldCode="AU" term="%22Lynch+RM%22">Lynch RM</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Magnuson+T%22">Magnuson T</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, School of Medicine, UNC-CH, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Murray+SA%22">Murray SA</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA.<br /><searchLink fieldCode="AU" term="%22Patel+S%22">Patel S</searchLink>; MMRRC-ICSC (Informatics, Coordination and Service Center), Genome Center, University of California-Davis (UC-D), Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Reinholdt+LG%22">Reinholdt LG</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA.<br /><searchLink fieldCode="AU" term="%22Sigmon+JS%22">Sigmon JS</searchLink>; MMRRC-UNC, UNC-CH, Chapel Hill, NC, USA.; Department of Computer Science, UNC-CH, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Willis+B%22">Willis B</searchLink>; MMRRC-UC Davis and Mouse Biology Program, UC-D, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xenakis+JG%22">Xenakis JG</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.
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