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Implantable living materials autonomously deliver therapeutics using contained engineered bacteria.

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Title: Implantable living materials autonomously deliver therapeutics using contained engineered bacteria.
Authors: Harimoto T; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Herrero Quevedo F; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Zillig J; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Schreiber S; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Wu Y; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Ahn CH; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., To T; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Thakur R; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA., Tatara AM; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Kang S; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Chen Z; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Lafuente-Gómez N; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Hanan B; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Pauer A; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Lightbown S; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Weitz DA; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Department of Physics, Harvard University, Cambridge, MA, USA., Mooney DJ; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Source: Science (New York, N.Y.) [Science] 2026 May 14; Vol. 392 (6799), pp. 729-734. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Harimoto+T%22">Harimoto T</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Herrero+Quevedo+F%22">Herrero Quevedo F</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zillig+J%22">Zillig J</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schreiber+S%22">Schreiber S</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ahn+CH%22">Ahn CH</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22To+T%22">To T</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Thakur+R%22">Thakur R</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tatara+AM%22">Tatara AM</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kang+S%22">Kang S</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lafuente-Gómez+N%22">Lafuente-Gómez N</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hanan+B%22">Hanan B</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pauer+A%22">Pauer A</searchLink>; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lightbown+S%22">Lightbown S</searchLink>; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Weitz+DA%22">Weitz DA</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Department of Physics, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mooney+DJ%22">Mooney DJ</searchLink>; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
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