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Machine learning-guided risk stratification for long QT syndrome genetic variants with hiPSC-derived cardiomyocytes.

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Title: Machine learning-guided risk stratification for long QT syndrome genetic variants with hiPSC-derived cardiomyocytes.
Authors: Khudiakov A; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy., Mura M; Translational Cardiology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Giannetti F; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy., Leonov V; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Surgery, Dentistry, Pediatrics and Gynecology, Cardiovascular Science, The University of Verona, Policlinico G.B. Rossi, Verona, Italy., Alberio C; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy., Eskandr M; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy., Lonati PA; Laboratory of ImmunoRheumatologic Researches, Istituto Auxologico Italiano IRCCS, Milan, Italy., Borghi MO; Laboratory of ImmunoRheumatologic Researches, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Dipartimento di Scienze Cliniche e di Comunità, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, Italy., Brink PA; Department of Medicine, University of Stellenbosch, Tygerberg, South Africa., Crotti L; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Gnecchi M; Translational Cardiology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Department of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, Italy., Schwartz PJ; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy., Sala L; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
Source: Cardiovascular research [Cardiovasc Res] 2026 Jul 11; Vol. 122 (10), pp. 1374-1390.
Publication Type: Journal Article
Journal Info: Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Machine learning-guided risk stratification for long QT syndrome genetic variants with hiPSC-derived cardiomyocytes.
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  Data: <searchLink fieldCode="AU" term="%22Khudiakov+A%22">Khudiakov A</searchLink>; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mura+M%22">Mura M</searchLink>; Translational Cardiology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Giannetti+F%22">Giannetti F</searchLink>; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Leonov+V%22">Leonov V</searchLink>; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Surgery, Dentistry, Pediatrics and Gynecology, Cardiovascular Science, The University of Verona, Policlinico G.B. Rossi, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Alberio+C%22">Alberio C</searchLink>; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Eskandr+M%22">Eskandr M</searchLink>; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Lonati+PA%22">Lonati PA</searchLink>; Laboratory of ImmunoRheumatologic Researches, Istituto Auxologico Italiano IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Borghi+MO%22">Borghi MO</searchLink>; Laboratory of ImmunoRheumatologic Researches, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Dipartimento di Scienze Cliniche e di Comunità, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Brink+PA%22">Brink PA</searchLink>; Department of Medicine, University of Stellenbosch, Tygerberg, South Africa.<br /><searchLink fieldCode="AU" term="%22Crotti+L%22">Crotti L</searchLink>; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gnecchi+M%22">Gnecchi M</searchLink>; Translational Cardiology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Department of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Schwartz+PJ%22">Schwartz PJ</searchLink>; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sala+L%22">Sala L</searchLink>; Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
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              Text: 2026 Jul 11
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