Tumor immune microenvironment reconstitution in patient-derived organoids enables therapy modeling for NSCLC.

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Title: Tumor immune microenvironment reconstitution in patient-derived organoids enables therapy modeling for NSCLC.
Authors: Podaza E; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA., Capuano J; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Kuo HH; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Al Assaad M; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Markowitz G; Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY 10021, USA., Revuelta MV; Department of Hematology and Oncology, Weill Cornell Medical College, New York, NY 10021, USA., Nguyen J; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Irizarry A; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Ravichandran H; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Ackermann S; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Kane T; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Manohar J; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Duren-Lubanski A; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Sigouros M; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Moyer J; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Bhinder B; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA., Chandra P; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA., Malbari M; Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY 10021, USA., Boehnke K; Eli Lilly and Company, Lilly Oncology, Discovery Technologies, New York, NY 10016, USA., Mosquera JM; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Mittal V; Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY 10021, USA., Sboner A; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA., Gokozan H; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Altorki N; Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY 10021, USA., Elemento O; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA., Martin ML; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: mlm4001@med.cornell.edu.
Source: Cell reports methods [Cell Rep Methods] 2026 Jun 15; Vol. 6 (6), pp. 101339. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918227360606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2667-2375 (Electronic) Linking ISSN: 26672375 NLM ISO Abbreviation: Cell Rep Methods Subsets: MEDLINE
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  Data: Tumor immune microenvironment reconstitution in patient-derived organoids enables therapy modeling for NSCLC.
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  Data: <searchLink fieldCode="AU" term="%22Podaza+E%22">Podaza E</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Capuano+J%22">Capuano J</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Kuo+HH%22">Kuo HH</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Al+Assaad+M%22">Al Assaad M</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Markowitz+G%22">Markowitz G</searchLink>; Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Revuelta+MV%22">Revuelta MV</searchLink>; Department of Hematology and Oncology, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+J%22">Nguyen J</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Irizarry+A%22">Irizarry A</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Ravichandran+H%22">Ravichandran H</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Ackermann+S%22">Ackermann S</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Kane+T%22">Kane T</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Manohar+J%22">Manohar J</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Duren-Lubanski+A%22">Duren-Lubanski A</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Sigouros+M%22">Sigouros M</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Moyer+J%22">Moyer J</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Bhinder+B%22">Bhinder B</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Chandra+P%22">Chandra P</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Malbari+M%22">Malbari M</searchLink>; Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Boehnke+K%22">Boehnke K</searchLink>; Eli Lilly and Company, Lilly Oncology, Discovery Technologies, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Mosquera+JM%22">Mosquera JM</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Mittal+V%22">Mittal V</searchLink>; Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Sboner+A%22">Sboner A</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Gokozan+H%22">Gokozan H</searchLink>; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Altorki+N%22">Altorki N</searchLink>; Cardiothoracic Surgery, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Elemento+O%22">Elemento O</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Martin+ML%22">Martin ML</searchLink>; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: mlm4001@med.cornell.edu.
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  Data: <searchLink fieldCode="JN" term="%229918227360606676%22">Cell reports methods</searchLink> [Cell Rep Methods] 2026 Jun 15; Vol. 6 (6), pp. 101339. <i>Date of Electronic Publication: </i>2026 May 13.
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