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Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3.

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Title: Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3.
Authors: Bressan C; Université Laval, Quebec City, QC G1V 0A6, Canada., Gengatharan A; Université Laval, Quebec City, QC G1V 0A6, Canada., Rodriguez-Aller R; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Richter ML; Division of Physiological Genomics, BioMedical Center, Ludwig-Maximilians-Universität München, Munich, Germany; Institute of Stem Cell Research, Helmholtz Center, Munich, Germany., Snapyan M; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Fischer-Sternjak J; Division of Physiological Genomics, BioMedical Center, Ludwig-Maximilians-Universität München, Munich, Germany; Institute of Stem Cell Research, Helmholtz Center, Munich, Germany., Roukerd MR; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Rosin N; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada., Cherinet A; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Biernaskie J; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada., Habibi E; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Ottawa, ON, Canada., Götz M; Division of Physiological Genomics, BioMedical Center, Ludwig-Maximilians-Universität München, Munich, Germany; Institute of Stem Cell Research, Helmholtz Center, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Saghatelyan A; Université Laval, Quebec City, QC G1V 0A6, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. Electronic address: asaghate@uottawa.ca.
Source: Neuron [Neuron] 2026 May 13. Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
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  Data: Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3.
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  Data: <searchLink fieldCode="AU" term="%22Bressan+C%22">Bressan C</searchLink>; Université Laval, Quebec City, QC G1V 0A6, Canada.<br /><searchLink fieldCode="AU" term="%22Gengatharan+A%22">Gengatharan A</searchLink>; Université Laval, Quebec City, QC G1V 0A6, Canada.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Aller+R%22">Rodriguez-Aller R</searchLink>; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Richter+ML%22">Richter ML</searchLink>; Division of Physiological Genomics, BioMedical Center, Ludwig-Maximilians-Universität München, Munich, Germany; Institute of Stem Cell Research, Helmholtz Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Snapyan+M%22">Snapyan M</searchLink>; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Fischer-Sternjak+J%22">Fischer-Sternjak J</searchLink>; Division of Physiological Genomics, BioMedical Center, Ludwig-Maximilians-Universität München, Munich, Germany; Institute of Stem Cell Research, Helmholtz Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Roukerd+MR%22">Roukerd MR</searchLink>; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Rosin+N%22">Rosin N</searchLink>; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Cherinet+A%22">Cherinet A</searchLink>; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Biernaskie+J%22">Biernaskie J</searchLink>; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Habibi+E%22">Habibi E</searchLink>; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Götz+M%22">Götz M</searchLink>; Division of Physiological Genomics, BioMedical Center, Ludwig-Maximilians-Universität München, Munich, Germany; Institute of Stem Cell Research, Helmholtz Center, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Saghatelyan+A%22">Saghatelyan A</searchLink>; Université Laval, Quebec City, QC G1V 0A6, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. Electronic address: asaghate@uottawa.ca.
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  Data: <searchLink fieldCode="JN" term="%228809320%22">Neuron</searchLink> [Neuron] 2026 May 13. <i>Date of Electronic Publication: </i>2026 May 13.
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