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Multi-locus genetic dosage shapes cognitive disease progression in Parkinson's patients: 15-year meta-analysis of 24 cohorts.

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Title: Multi-locus genetic dosage shapes cognitive disease progression in Parkinson's patients: 15-year meta-analysis of 24 cohorts.
Authors: Kang X; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT, 06510, USA.; Departments of Neurology, Genetics, and Neuroscience, Yale School of Medicine, New Haven, CT, 06510, USA., Lin Z; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT, 06510, USA.; Departments of Neurology, Genetics, and Neuroscience, Yale School of Medicine, New Haven, CT, 06510, USA., Calikusu FZ; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT, 06510, USA.; Departments of Neurology, Genetics, and Neuroscience, Yale School of Medicine, New Haven, CT, 06510, USA., Miller LA; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT, 06510, USA.; Departments of Neurology, Genetics, and Neuroscience, Yale School of Medicine, New Haven, CT, 06510, USA., Soriano S; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT, 06510, USA.; Departments of Neurology, Genetics, and Neuroscience, Yale School of Medicine, New Haven, CT, 06510, USA., Locascio JJ; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Corvol JC; Sorbonne Université, Paris Brain Institute, Institut du Cerveau (ICM), Institut National de Santé et en Recherche Médicale, Centre National de Recherche Scientifique, Assistance Publique Hôpitaux de Paris, Département de Neurologie et de Génétique, Centre d'Investigation Clinique Neurosciences, Hôpital Pitié-Salpêtrière, Paris, France., Maple-Grødem J; The Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway., Fan Y; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT, 06510, USA.; Departments of Neurology, Genetics, and Neuroscience, Yale School of Medicine, New Haven, CT, 06510, USA.; Department of Neurology, Peking University People's Hospital, Beijing, China., Mead K; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT, 06510, USA.; Departments of Neurology, Genetics, and Neuroscience, Yale School of Medicine, New Haven, CT, 06510, USA., Campbell MC; Departments of Neurology and Radiology, Washington University School of Medicine, St. Louis, MO, USA., Elbaz A; Paris-Saclay University, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Inserm, Gustave Roussy, 'Exposome and heredity' team, Centre de Researche en Epidémiologie et Santé des Populations (CESP), Villejuif, France., Lesage S; Sorbonne Université, Paris Brain Institute, Institut du Cerveau (ICM), Institut National de Santé et en Recherche Médicale, Centre National de Recherche Scientifique, Assistance Publique Hôpitaux de Paris, Département de Neurologie et de Génétique, Centre d'Investigation Clinique Neurosciences, Hôpital Pitié-Salpêtrière, Paris, France., Brice A; Sorbonne Université, Paris Brain Institute, Institut du Cerveau (ICM), Institut National de Santé et en Recherche Médicale, Centre National de Recherche Scientifique, Assistance Publique Hôpitaux de Paris, Département de Neurologie et de Génétique, Centre d'Investigation Clinique Neurosciences, Hôpital Pitié-Salpêtrière, Paris, France., Hung AY; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Schwarzschild MA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Hayes MT; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Wills AM; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Herrington TM; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Liu G; School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, China., Ravina B; Praxis Precision Medicines, Cambridge, MA, USA, and Department of Neurology, Center for Health Technology, University of Rochester, Rochester, NY, USA., Taba P; Department of Neurology and Neurosurgery, University of Tartu, and Clinic of Neurology, Tartu University Hospital, Tartu, Estonia., Kõks S; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Western Australia, Australia.; Perron Institute for Neurological and Translational Science, Perth, Western Australia, Australia., Simuni T; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Forsgren L; Department of Clinical Science, Neurosciences, Umeå University, Umeå, Sweden., Counsell C; Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK., Macleod AD; Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK., Beach TG; Banner Sun Health Research Institute, Sun City, AZ, USA., Alves G; The Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway.; Department of Neurology, Stavanger University Hospital, Stavanger, Norway., Tysnes OB; Department of Neurology, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway., Perlmutter JS; Departments of Neurology and Radiology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA.; Programs of Physical Therapy and Program of Occupational Therapy, Washington University School of Medicine, St. Louis, MO, USA., Heutink P; Institute of Neurogenetics, University of Lübeck, University Hospital of Schleswig-Holstein, Lübeck, Germany., Kasten M; Institute of Neurogenetics, University of Lübeck, University Hospital of Schleswig-Holstein, Lübeck, Germany.; Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany., Mollenhauer B; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.; Paracelsus-Elena-Klinik, Kassel, Germany., Trenkwalder C; Paracelsus-Elena-Klinik, Kassel, Germany.; Department of Neurosurgery, University Medical Center Göttingen, Göttingen, Germany., Klein C; Institute of Neurogenetics, University of Lübeck, University Hospital of Schleswig-Holstein, Lübeck, Germany., Hepp DH; Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands., Backstrom D; Department of Clinical Science, Neurosciences, Umeå University, Umeå, Sweden., Svenningsson P; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Hu MT; Nuffield Department Clinical Neurosciences, University of Oxford, Oxford, UK., Williams-Gray CH; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Barker RA; John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Scherzer CR; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT, 06510, USA. clemens.scherzer@yale.edu.; Departments of Neurology, Genetics, and Neuroscience, Yale School of Medicine, New Haven, CT, 06510, USA. clemens.scherzer@yale.edu.; Prior address: Precision Neurology Program and APDA Center for Advanced Research of Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. clemens.scherzer@yale.edu.
Corporate Authors: International Genetics of Parkinson Disease Progression (IGPP) Consortium
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2026 May 14. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis
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  Data: <searchLink fieldCode="AU" term="%22Kang+X%22">Kang X</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT, 06510, USA.; Departments of Neurology, Genetics, and Neuroscience, Yale School of Medicine, New Haven, CT, 06510, USA.<br /><searchLink fieldCode="AU" term="%22Lin+Z%22">Lin Z</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT, 06510, USA.; Departments of Neurology, Genetics, and Neuroscience, Yale School of Medicine, New Haven, CT, 06510, USA.<br /><searchLink fieldCode="AU" term="%22Calikusu+FZ%22">Calikusu FZ</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT, 06510, USA.; Departments of Neurology, Genetics, and Neuroscience, Yale School of Medicine, New Haven, CT, 06510, USA.<br /><searchLink fieldCode="AU" term="%22Miller+LA%22">Miller LA</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT, 06510, USA.; 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          Identifiers:
            – Type: issn-print
              Value: 2373-8057
          Titles:
            – TitleFull: NPJ Parkinson's disease
              Type: main
ResultId 1