Bi-directional regulation between NAD/NAMPT and IFN-γ/PD-L1 axes via BRD4/IRF1 and mitochondrial respiration in metastatic cutaneous melanoma.
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| Title: | Bi-directional regulation between NAD/NAMPT and IFN-γ/PD-L1 axes via BRD4/IRF1 and mitochondrial respiration in metastatic cutaneous melanoma. |
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| Authors: | Fiorilla I; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Ghezzi B; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Ponzano A; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Moiso E; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Riccardo F; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Tommasi N; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Avalle L; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Carrà G; San Luigi Gonzaga Hospital, Regione Gonzole, Orbassano, Italy.; Department of Clinical and Biological Sciences, University of Turin, Torino, Italy., Ugolini F; Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy., Calussi E; Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy., Todesco AM; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Digiovanni S; Department of Oncology, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Casone F; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Rizza G; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Ponzone L; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Szumera-Ciećkiewicz A; Biobank, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.; Department of Pathology and Laboratory Medicine, Maria Sklodowska- Curie National Research Institute of Oncology, Warsaw, Poland., Cavaletto M; Department of Sustainable Development and Ecological Transition, University of Eastern Piedmont, Vercelli, Italy., Porporato PE; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Conti L; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Riganti C; Department of Oncology, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Massi D; Department of Health Sciences, Section of Pathology, University of Florence, Florence, Italy.; Department of Molecular Pathobiology, New York University - College of Dentistry, New York, USA., Calautti E; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Audrito V; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy. valentina.audrito@uniupo.it.; Research Laboratories, Research and Innovation Department (DAIRI), Azienda Ospedaliera Universitaria AOU 'SS. Antonio e Biagio e Cesare Arrigo', Alessandria, Italy. valentina.audrito@uniupo.it. |
| Source: | Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 May 14; Vol. 45 (1). Date of Electronic Publication: 2026 May 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42135764 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Bi-directional regulation between NAD/NAMPT and IFN-γ/PD-L1 axes via BRD4/IRF1 and mitochondrial respiration in metastatic cutaneous melanoma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Fiorilla+I%22">Fiorilla I</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Ghezzi+B%22">Ghezzi B</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Ponzano+A%22">Ponzano A</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Moiso+E%22">Moiso E</searchLink>; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Riccardo+F%22">Riccardo F</searchLink>; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Tommasi+N%22">Tommasi N</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Avalle+L%22">Avalle L</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Carrà+G%22">Carrà G</searchLink>; San Luigi Gonzaga Hospital, Regione Gonzole, Orbassano, Italy.; Department of Clinical and Biological Sciences, University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Ugolini+F%22">Ugolini F</searchLink>; Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Calussi+E%22">Calussi E</searchLink>; Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Todesco+AM%22">Todesco AM</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Digiovanni+S%22">Digiovanni S</searchLink>; Department of Oncology, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Casone+F%22">Casone F</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Rizza+G%22">Rizza G</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Ponzone+L%22">Ponzone L</searchLink>; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Szumera-Ciećkiewicz+A%22">Szumera-Ciećkiewicz A</searchLink>; Biobank, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.; Department of Pathology and Laboratory Medicine, Maria Sklodowska- Curie National Research Institute of Oncology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Cavaletto+M%22">Cavaletto M</searchLink>; Department of Sustainable Development and Ecological Transition, University of Eastern Piedmont, Vercelli, Italy.<br /><searchLink fieldCode="AU" term="%22Porporato+PE%22">Porporato PE</searchLink>; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Conti+L%22">Conti L</searchLink>; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Riganti+C%22">Riganti C</searchLink>; Department of Oncology, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Massi+D%22">Massi D</searchLink>; Department of Health Sciences, Section of Pathology, University of Florence, Florence, Italy.; Department of Molecular Pathobiology, New York University - College of Dentistry, New York, USA.<br /><searchLink fieldCode="AU" term="%22Calautti+E%22">Calautti E</searchLink>; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Audrito+V%22">Audrito V</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy. valentina.audrito@uniupo.it.; Research Laboratories, Research and Innovation Department (DAIRI), Azienda Ospedaliera Universitaria AOU 'SS. Antonio e Biagio e Cesare Arrigo', Alessandria, Italy. valentina.audrito@uniupo.it. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228308647%22">Journal of experimental & clinical cancer research : CR</searchLink> [J Exp Clin Cancer Res] 2026 May 14; Vol. 45 (1). <i>Date of Electronic Publication: </i>2026 May 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8308647 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1756-9966 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203929078%22">03929078 </searchLink><i>NLM ISO Abbreviation: </i>J Exp Clin Cancer Res <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42135764 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s13046-026-03734-2 Languages: – Code: eng Text: English Titles: – TitleFull: Bi-directional regulation between NAD/NAMPT and IFN-γ/PD-L1 axes via BRD4/IRF1 and mitochondrial respiration in metastatic cutaneous melanoma. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fiorilla I – PersonEntity: Name: NameFull: Ghezzi B – PersonEntity: Name: NameFull: Ponzano A – PersonEntity: Name: NameFull: Moiso E – PersonEntity: Name: NameFull: Riccardo F – PersonEntity: Name: NameFull: Tommasi N – PersonEntity: Name: NameFull: Avalle L – PersonEntity: Name: NameFull: Carrà G – PersonEntity: Name: NameFull: Ugolini F – PersonEntity: Name: NameFull: Calussi E – PersonEntity: Name: NameFull: Todesco AM – PersonEntity: Name: NameFull: Digiovanni S – PersonEntity: Name: NameFull: Casone F – PersonEntity: Name: NameFull: Rizza G – PersonEntity: Name: NameFull: Ponzone L – PersonEntity: Name: NameFull: Szumera-Ciećkiewicz A – PersonEntity: Name: NameFull: Cavaletto M – PersonEntity: Name: NameFull: Porporato PE – PersonEntity: Name: NameFull: Conti L – PersonEntity: Name: NameFull: Riganti C – PersonEntity: Name: NameFull: Massi D – PersonEntity: Name: NameFull: Calautti E – PersonEntity: Name: NameFull: Audrito V IsPartOfRelationships: – BibEntity: Dates: – D: 14 M: 05 Text: 2026 May 14 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1756-9966 Numbering: – Type: volume Value: 45 – Type: issue Value: 1 Titles: – TitleFull: Journal of experimental & clinical cancer research : CR Type: main |
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