Bi-directional regulation between NAD/NAMPT and IFN-γ/PD-L1 axes via BRD4/IRF1 and mitochondrial respiration in metastatic cutaneous melanoma.

Saved in:
Bibliographic Details
Title: Bi-directional regulation between NAD/NAMPT and IFN-γ/PD-L1 axes via BRD4/IRF1 and mitochondrial respiration in metastatic cutaneous melanoma.
Authors: Fiorilla I; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Ghezzi B; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Ponzano A; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Moiso E; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Riccardo F; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Tommasi N; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Avalle L; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Carrà G; San Luigi Gonzaga Hospital, Regione Gonzole, Orbassano, Italy.; Department of Clinical and Biological Sciences, University of Turin, Torino, Italy., Ugolini F; Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy., Calussi E; Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy., Todesco AM; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Digiovanni S; Department of Oncology, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Casone F; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Rizza G; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy., Ponzone L; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Szumera-Ciećkiewicz A; Biobank, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.; Department of Pathology and Laboratory Medicine, Maria Sklodowska- Curie National Research Institute of Oncology, Warsaw, Poland., Cavaletto M; Department of Sustainable Development and Ecological Transition, University of Eastern Piedmont, Vercelli, Italy., Porporato PE; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Conti L; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Riganti C; Department of Oncology, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Massi D; Department of Health Sciences, Section of Pathology, University of Florence, Florence, Italy.; Department of Molecular Pathobiology, New York University - College of Dentistry, New York, USA., Calautti E; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy., Audrito V; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy. valentina.audrito@uniupo.it.; Research Laboratories, Research and Innovation Department (DAIRI), Azienda Ospedaliera Universitaria AOU 'SS. Antonio e Biagio e Cesare Arrigo', Alessandria, Italy. valentina.audrito@uniupo.it.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 May 14; Vol. 45 (1). Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42135764
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Bi-directional regulation between NAD/NAMPT and IFN-γ/PD-L1 axes via BRD4/IRF1 and mitochondrial respiration in metastatic cutaneous melanoma.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Fiorilla+I%22">Fiorilla I</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Ghezzi+B%22">Ghezzi B</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Ponzano+A%22">Ponzano A</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Moiso+E%22">Moiso E</searchLink>; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Riccardo+F%22">Riccardo F</searchLink>; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Tommasi+N%22">Tommasi N</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Avalle+L%22">Avalle L</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Carrà+G%22">Carrà G</searchLink>; San Luigi Gonzaga Hospital, Regione Gonzole, Orbassano, Italy.; Department of Clinical and Biological Sciences, University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Ugolini+F%22">Ugolini F</searchLink>; Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Calussi+E%22">Calussi E</searchLink>; Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Todesco+AM%22">Todesco AM</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Digiovanni+S%22">Digiovanni S</searchLink>; Department of Oncology, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Casone+F%22">Casone F</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Rizza+G%22">Rizza G</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Ponzone+L%22">Ponzone L</searchLink>; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Szumera-Ciećkiewicz+A%22">Szumera-Ciećkiewicz A</searchLink>; Biobank, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.; Department of Pathology and Laboratory Medicine, Maria Sklodowska- Curie National Research Institute of Oncology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Cavaletto+M%22">Cavaletto M</searchLink>; Department of Sustainable Development and Ecological Transition, University of Eastern Piedmont, Vercelli, Italy.<br /><searchLink fieldCode="AU" term="%22Porporato+PE%22">Porporato PE</searchLink>; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Conti+L%22">Conti L</searchLink>; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Riganti+C%22">Riganti C</searchLink>; Department of Oncology, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Massi+D%22">Massi D</searchLink>; Department of Health Sciences, Section of Pathology, University of Florence, Florence, Italy.; Department of Molecular Pathobiology, New York University - College of Dentistry, New York, USA.<br /><searchLink fieldCode="AU" term="%22Calautti+E%22">Calautti E</searchLink>; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center 'Guido Tarone', University of Turin, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Audrito+V%22">Audrito V</searchLink>; Department of Science and Technological Innovation, University of Eastern Piedmont, Alessandria, Italy. valentina.audrito@uniupo.it.; Research Laboratories, Research and Innovation Department (DAIRI), Azienda Ospedaliera Universitaria AOU 'SS. Antonio e Biagio e Cesare Arrigo', Alessandria, Italy. valentina.audrito@uniupo.it.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%228308647%22">Journal of experimental & clinical cancer research : CR</searchLink> [J Exp Clin Cancer Res] 2026 May 14; Vol. 45 (1). <i>Date of Electronic Publication: </i>2026 May 14.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8308647 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1756-9966 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203929078%22">03929078 </searchLink><i>NLM ISO Abbreviation: </i>J Exp Clin Cancer Res <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42135764
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1186/s13046-026-03734-2
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Bi-directional regulation between NAD/NAMPT and IFN-γ/PD-L1 axes via BRD4/IRF1 and mitochondrial respiration in metastatic cutaneous melanoma.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Fiorilla I
      – PersonEntity:
          Name:
            NameFull: Ghezzi B
      – PersonEntity:
          Name:
            NameFull: Ponzano A
      – PersonEntity:
          Name:
            NameFull: Moiso E
      – PersonEntity:
          Name:
            NameFull: Riccardo F
      – PersonEntity:
          Name:
            NameFull: Tommasi N
      – PersonEntity:
          Name:
            NameFull: Avalle L
      – PersonEntity:
          Name:
            NameFull: Carrà G
      – PersonEntity:
          Name:
            NameFull: Ugolini F
      – PersonEntity:
          Name:
            NameFull: Calussi E
      – PersonEntity:
          Name:
            NameFull: Todesco AM
      – PersonEntity:
          Name:
            NameFull: Digiovanni S
      – PersonEntity:
          Name:
            NameFull: Casone F
      – PersonEntity:
          Name:
            NameFull: Rizza G
      – PersonEntity:
          Name:
            NameFull: Ponzone L
      – PersonEntity:
          Name:
            NameFull: Szumera-Ciećkiewicz A
      – PersonEntity:
          Name:
            NameFull: Cavaletto M
      – PersonEntity:
          Name:
            NameFull: Porporato PE
      – PersonEntity:
          Name:
            NameFull: Conti L
      – PersonEntity:
          Name:
            NameFull: Riganti C
      – PersonEntity:
          Name:
            NameFull: Massi D
      – PersonEntity:
          Name:
            NameFull: Calautti E
      – PersonEntity:
          Name:
            NameFull: Audrito V
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 14
              M: 05
              Text: 2026 May 14
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1756-9966
          Numbering:
            – Type: volume
              Value: 45
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Journal of experimental & clinical cancer research : CR
              Type: main
ResultId 1