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Stiffness-dependent CMOT hydrogels promote mucosal repair in ulcerative colitis through YAP‑mediated mechanosensing in intestinal epithelial cells.

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Title: Stiffness-dependent CMOT hydrogels promote mucosal repair in ulcerative colitis through YAP‑mediated mechanosensing in intestinal epithelial cells.
Authors: Chen G; First Affiliated Hospital, Postdoctoral Research Station, Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China., Fang Z; First Affiliated Hospital, Postdoctoral Research Station, Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China., Feng M; First Affiliated Hospital, Postdoctoral Research Station, Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China., Ye Z; The Affiliated Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan, 523000, China., Gu Z; Department of Basic Medicine and Medical Technology, School of Medicine, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, The Affiliated Hospital of Yangzhou University, Yangzhou, 225000, China., Xu Y; First Affiliated Hospital, Postdoctoral Research Station, Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China., Wu H; The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510006, China., Tu B; Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, 528400, China., Xiong W; Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, 528400, China., Ma X; First Affiliated Hospital, Postdoctoral Research Station, Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. maxiangxue@163.com.; First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. maxiangxue@163.com., Huang Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. yzhuang@simm.ac.cn., Huang S; First Affiliated Hospital, Postdoctoral Research Station, Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. huangshaogang@gzucm.edu.cn.; First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. huangshaogang@gzucm.edu.cn.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 May 14; Vol. 24 (1). Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Stiffness-dependent CMOT hydrogels promote mucosal repair in ulcerative colitis through YAP‑mediated mechanosensing in intestinal epithelial cells.
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  Data: <searchLink fieldCode="AU" term="%22Chen+G%22">Chen G</searchLink>; First Affiliated Hospital, Postdoctoral Research Station, Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.<br /><searchLink fieldCode="AU" term="%22Fang+Z%22">Fang Z</searchLink>; First Affiliated Hospital, Postdoctoral Research Station, Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.<br /><searchLink fieldCode="AU" term="%22Feng+M%22">Feng M</searchLink>; First Affiliated Hospital, Postdoctoral Research Station, Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.<br /><searchLink fieldCode="AU" term="%22Ye+Z%22">Ye Z</searchLink>; The Affiliated Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan, 523000, China.<br /><searchLink fieldCode="AU" term="%22Gu+Z%22">Gu Z</searchLink>; Department of Basic Medicine and Medical Technology, School of Medicine, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, The Affiliated Hospital of Yangzhou University, Yangzhou, 225000, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; First Affiliated Hospital, Postdoctoral Research Station, Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Tu+B%22">Tu B</searchLink>; Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, 528400, China.<br /><searchLink fieldCode="AU" term="%22Xiong+W%22">Xiong W</searchLink>; Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, 528400, China.<br /><searchLink fieldCode="AU" term="%22Ma+X%22">Ma X</searchLink>; First Affiliated Hospital, Postdoctoral Research Station, Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. maxiangxue@163.com.; First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. maxiangxue@163.com.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. yzhuang@simm.ac.cn.<br /><searchLink fieldCode="AU" term="%22Huang+S%22">Huang S</searchLink>; First Affiliated Hospital, Postdoctoral Research Station, Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. huangshaogang@gzucm.edu.cn.; First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. huangshaogang@gzucm.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101152208%22">Journal of nanobiotechnology</searchLink> [J Nanobiotechnology] 2026 May 14; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 May 14.
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      – TitleFull: Stiffness-dependent CMOT hydrogels promote mucosal repair in ulcerative colitis through YAP‑mediated mechanosensing in intestinal epithelial cells.
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              Text: 2026 May 14
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