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KLRG1 silencing increases the efficacy of CAR NK cell therapy against colon cancer via SHP-2/ZAP-70/NF-κB signal pathway.

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Title: KLRG1 silencing increases the efficacy of CAR NK cell therapy against colon cancer via SHP-2/ZAP-70/NF-κB signal pathway.
Authors: Chen Y; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China., Farooq MA; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.; Department of Precision Medicine, The first Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523000, China., Hui X; The First Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, 510120, China.; Guangzhou National Laboratory, Guangzhou, 510005, China., Huang Y; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China., Hu Y; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China., Xue M; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China., Ajmal I; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.; Guangdong Provincial key laboratory of Medical Immunology and Molecular Diagnostics, School of Medical Lab Technology, Guangdong Medical University, Dongguan, 510260, China., Ren Y; College of Life Science, Xinjiang Normal University, Urumqi, China., Ji Y; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China., Wang C; Department of Oncology, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai, 200092, China. wangchenchina@126.com., Jiang W; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China. wzjiang@bio.ecnu.edu.cn.; Shanghai NTBIO Therapeutics Co., Ltd., Shanghai, 200241, China. wzjiang@bio.ecnu.edu.cn.
Source: Journal of translational medicine [J Transl Med] 2026 May 14; Vol. 24 (1). Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: KLRG1 silencing increases the efficacy of CAR NK cell therapy against colon cancer via SHP-2/ZAP-70/NF-κB signal pathway.
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  Data: <searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.<br /><searchLink fieldCode="AU" term="%22Farooq+MA%22">Farooq MA</searchLink>; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.; Department of Precision Medicine, The first Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523000, China.<br /><searchLink fieldCode="AU" term="%22Hui+X%22">Hui X</searchLink>; The First Affiliated Hospital, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, 510120, China.; Guangzhou National Laboratory, Guangzhou, 510005, China.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.<br /><searchLink fieldCode="AU" term="%22Hu+Y%22">Hu Y</searchLink>; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.<br /><searchLink fieldCode="AU" term="%22Xue+M%22">Xue M</searchLink>; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.<br /><searchLink fieldCode="AU" term="%22Ajmal+I%22">Ajmal I</searchLink>; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.; Guangdong Provincial key laboratory of Medical Immunology and Molecular Diagnostics, School of Medical Lab Technology, Guangdong Medical University, Dongguan, 510260, China.<br /><searchLink fieldCode="AU" term="%22Ren+Y%22">Ren Y</searchLink>; College of Life Science, Xinjiang Normal University, Urumqi, China.<br /><searchLink fieldCode="AU" term="%22Ji+Y%22">Ji Y</searchLink>; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Department of Oncology, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai, 200092, China. wangchenchina@126.com.<br /><searchLink fieldCode="AU" term="%22Jiang+W%22">Jiang W</searchLink>; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China. wzjiang@bio.ecnu.edu.cn.; Shanghai NTBIO Therapeutics Co., Ltd., Shanghai, 200241, China. wzjiang@bio.ecnu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 May 14; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 May 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12967-026-08267-y
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        Text: English
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      – TitleFull: KLRG1 silencing increases the efficacy of CAR NK cell therapy against colon cancer via SHP-2/ZAP-70/NF-κB signal pathway.
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            – D: 14
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              Text: 2026 May 14
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