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Comprehensive Review of Genetic and Epigenetic Regulation of Fetal Hemoglobin in β-Hemoglobinopathies: From Molecular Mechanisms to Clinical Applications.

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Title: Comprehensive Review of Genetic and Epigenetic Regulation of Fetal Hemoglobin in β-Hemoglobinopathies: From Molecular Mechanisms to Clinical Applications.
Authors: Abu Za'ror YSM; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jerash University, Amman-Irbid Highway, P.O. Box 26150, Jerash, Jordan., Suleiman JB; Department of Science Laboratory Technology, School of Science, Akanu Ibiam Federal Polytechnic, Unwana, Afikpo, Ebonyi State., Delmani FA; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jerash University, Amman-Irbid Highway, P.O. Box 26150, Jerash, Jordan., Alhmoud JF; Department of Medical Laboratory Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan., Ayasreh AM; Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Zarqa University, Zarqa, Jordan., Al-Wendawi SI; Jordan University of Science and Technology, Irbid, Jordan., AlRamadneh TN; Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, P.O. Box: 19328, Jordan., Azlan M; School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
Source: Mediterranean journal of hematology and infectious diseases [Mediterr J Hematol Infect Dis] 2026 May 01; Vol. 18 (1), pp. e2026046. Date of Electronic Publication: 2026 May 01 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Università Cattolica del Sacro Cuore Country of Publication: Italy NLM ID: 101530512 Publication Model: eCollection Cited Medium: Print ISSN: 2035-3006 (Print) Linking ISSN: 20353006 NLM ISO Abbreviation: Mediterr J Hematol Infect Dis Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Comprehensive Review of Genetic and Epigenetic Regulation of Fetal Hemoglobin in β-Hemoglobinopathies: From Molecular Mechanisms to Clinical Applications.
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  Data: <searchLink fieldCode="AU" term="%22Abu+Za'ror+YSM%22">Abu Za'ror YSM</searchLink>; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jerash University, Amman-Irbid Highway, P.O. Box 26150, Jerash, Jordan.<br /><searchLink fieldCode="AU" term="%22Suleiman+JB%22">Suleiman JB</searchLink>; Department of Science Laboratory Technology, School of Science, Akanu Ibiam Federal Polytechnic, Unwana, Afikpo, Ebonyi State.<br /><searchLink fieldCode="AU" term="%22Delmani+FA%22">Delmani FA</searchLink>; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jerash University, Amman-Irbid Highway, P.O. Box 26150, Jerash, Jordan.<br /><searchLink fieldCode="AU" term="%22Alhmoud+JF%22">Alhmoud JF</searchLink>; Department of Medical Laboratory Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan.<br /><searchLink fieldCode="AU" term="%22Ayasreh+AM%22">Ayasreh AM</searchLink>; Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Zarqa University, Zarqa, Jordan.<br /><searchLink fieldCode="AU" term="%22Al-Wendawi+SI%22">Al-Wendawi SI</searchLink>; Jordan University of Science and Technology, Irbid, Jordan.<br /><searchLink fieldCode="AU" term="%22AlRamadneh+TN%22">AlRamadneh TN</searchLink>; Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, P.O. Box: 19328, Jordan.<br /><searchLink fieldCode="AU" term="%22Azlan+M%22">Azlan M</searchLink>; School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
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  Data: <searchLink fieldCode="JN" term="%22101530512%22">Mediterranean journal of hematology and infectious diseases</searchLink> [Mediterr J Hematol Infect Dis] 2026 May 01; Vol. 18 (1), pp. e2026046. <i>Date of Electronic Publication: </i>2026 May 01 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Università+Cattolica+del+Sacro+Cuore%22">Università Cattolica del Sacro Cuore </searchLink><i>Country of Publication: </i>Italy <i>NLM ID: </i>101530512 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2035-3006 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220353006%22">20353006 </searchLink><i>NLM ISO Abbreviation: </i>Mediterr J Hematol Infect Dis <i>Subsets: </i>PubMed not MEDLINE
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      – Type: doi
        Value: 10.4084/MJHID.2026.046
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      – Code: eng
        Text: English
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        StartPage: e2026046
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      – TitleFull: Comprehensive Review of Genetic and Epigenetic Regulation of Fetal Hemoglobin in β-Hemoglobinopathies: From Molecular Mechanisms to Clinical Applications.
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              Text: 2026 May 01
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              Y: 2026
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