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Exploiting CDA-Mediated metabolism of 5fdC to overcome cytarabine resistance in Malignant myeloid cells leukemia.

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Title: Exploiting CDA-Mediated metabolism of 5fdC to overcome cytarabine resistance in Malignant myeloid cells leukemia.
Authors: Fan A; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China., Dong M; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China., Fan N; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China., Luo Q; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China., Mo J; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China., Ai L; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China., Zhou Y; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China. Electronic address: zhouyanhua@gmc.edu.cn., Zhang P; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China. Electronic address: peng12zhang@gmc.edu.cn.
Source: Biochemical pharmacology [Biochem Pharmacol] 2026 Sep; Vol. 251 (Pt 1), pp. 118064. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exploiting CDA-Mediated metabolism of 5fdC to overcome cytarabine resistance in Malignant myeloid cells leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Fan+A%22">Fan A</searchLink>; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China.<br /><searchLink fieldCode="AU" term="%22Dong+M%22">Dong M</searchLink>; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China.<br /><searchLink fieldCode="AU" term="%22Fan+N%22">Fan N</searchLink>; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China.<br /><searchLink fieldCode="AU" term="%22Luo+Q%22">Luo Q</searchLink>; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China.<br /><searchLink fieldCode="AU" term="%22Mo+J%22">Mo J</searchLink>; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China.<br /><searchLink fieldCode="AU" term="%22Ai+L%22">Ai L</searchLink>; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China. Electronic address: zhouyanhua@gmc.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Functional Nucleic Acids-Based Biopharmaceutical Research, Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, China; Key Laboratory for Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Guiyang 550004, China. Electronic address: peng12zhang@gmc.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%220101032%22">Biochemical pharmacology</searchLink> [Biochem Pharmacol] 2026 Sep; Vol. 251 (Pt 1), pp. 118064. <i>Date of Electronic Publication: </i>2026 May 14.
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        Value: 10.1016/j.bcp.2026.118064
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              M: 09
              Text: 2026 Sep
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