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Flavonoid-rich extract of Cereus jamacaru: safety assessment and protective effects via NF-κB/MAPK modulation in an acute intestinal inflammation model.

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Title: Flavonoid-rich extract of Cereus jamacaru: safety assessment and protective effects via NF-κB/MAPK modulation in an acute intestinal inflammation model.
Authors: da Costa Melo NM; Research Group of Bioactive Natural Products, Health Sciences Center, Pharmacy Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil; Postgraduate Program in Biochemistry and Molecular Biology, Biosciences Center, Federal University of Rio Grande Norte, Natal, Brazil; Postgraduate Program in Development and Technological Innovation in Medicines, Health Sciences Center, Natal, Rio Grande do Norte, Brazil. Electronic address: nadja.melo.094@ufrn.edu.br., de Souza Araújo DF; Health Sciences College of Trairi, Department of Nutrition, Federal University of Rio Grande do Norte, Santa Cruz, Brazil. Electronic address: daline.araujo@ufrn.br., Dantas-Medeiros R; Research Group of Bioactive Natural Products, Health Sciences Center, Pharmacy Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil; Postgraduate Program in Development and Technological Innovation in Medicines, Health Sciences Center, Natal, Rio Grande do Norte, Brazil. Electronic address: renato.medeiros.071@ufrn.edu.br., da Silva VC; Research Group of Bioactive Natural Products, Health Sciences Center, Pharmacy Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil; Postgraduate Program in Development and Technological Innovation in Medicines, Health Sciences Center, Natal, Rio Grande do Norte, Brazil. Electronic address: valeria.costa.098@ufrn.edu.br., de Aragão Tavares E; Health Sciences Center, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, Natal, Brazil; Research Group of Bioactive Natural Products, Health Sciences Center, Pharmacy Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Electronic address: emanuella_ta@hotmail.com., Pinheiro FASD; Health Sciences Center, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, Natal, Brazil. Electronic address: ayrtonsennap@gmail.com., De Santis Ferreira L; Health Sciences Center, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, Natal, Brazil. Electronic address: leandro.ferreira@ufrn.br., Zanatta AC; Faculty of Pharmaceutical Science of Ribeirão Preto, University of São Paulo, USP, Ribeirão Preto, São Paulo, Brazil. Electronic address: anaczanatta@gmail.com., de Moura DR; Faculty of Pharmaceutical Science of Ribeirão Preto, University of São Paulo, USP, Ribeirão Preto, São Paulo, Brazil. Electronic address: diegomoura@usp.br., de Araujo AA; Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil. Electronic address: aurigena.antunes@ufrn.br., de Araújo Júnior RF; Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil. Electronic address: fernandes.araujo@ufrn.br., Guerra GCB; Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil; Postgraduate Program in Biochemistry and Molecular Biology, Biosciences Center, Federal University of Rio Grande Norte, Natal, Brazil. Electronic address: gerlane.guerra@ufrn.br., Zucolotto SM; Health Sciences Center, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, Natal, Brazil; Research Group of Bioactive Natural Products, Health Sciences Center, Pharmacy Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil; Postgraduate Program in Development and Technological Innovation in Medicines, Health Sciences Center, Natal, Rio Grande do Norte, Brazil. Electronic address: silvana.zucolotto@ufrn.br.
Source: Journal of ethnopharmacology [J Ethnopharmacol] 2026 Oct 28; Vol. 369, pp. 121818. Date of Electronic Publication: 2026 May 14.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE
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  Data: Flavonoid-rich extract of Cereus jamacaru: safety assessment and protective effects via NF-κB/MAPK modulation in an acute intestinal inflammation model.
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  Data: <searchLink fieldCode="AU" term="%22da+Costa+Melo+NM%22">da Costa Melo NM</searchLink>; Research Group of Bioactive Natural Products, Health Sciences Center, Pharmacy Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil; Postgraduate Program in Biochemistry and Molecular Biology, Biosciences Center, Federal University of Rio Grande Norte, Natal, Brazil; Postgraduate Program in Development and Technological Innovation in Medicines, Health Sciences Center, Natal, Rio Grande do Norte, Brazil. Electronic address: nadja.melo.094@ufrn.edu.br.<br /><searchLink fieldCode="AU" term="%22de+Souza+Araújo+DF%22">de Souza Araújo DF</searchLink>; Health Sciences College of Trairi, Department of Nutrition, Federal University of Rio Grande do Norte, Santa Cruz, Brazil. Electronic address: daline.araujo@ufrn.br.<br /><searchLink fieldCode="AU" term="%22Dantas-Medeiros+R%22">Dantas-Medeiros R</searchLink>; Research Group of Bioactive Natural Products, Health Sciences Center, Pharmacy Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil; Postgraduate Program in Development and Technological Innovation in Medicines, Health Sciences Center, Natal, Rio Grande do Norte, Brazil. Electronic address: renato.medeiros.071@ufrn.edu.br.<br /><searchLink fieldCode="AU" term="%22da+Silva+VC%22">da Silva VC</searchLink>; Research Group of Bioactive Natural Products, Health Sciences Center, Pharmacy Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil; Postgraduate Program in Development and Technological Innovation in Medicines, Health Sciences Center, Natal, Rio Grande do Norte, Brazil. Electronic address: valeria.costa.098@ufrn.edu.br.<br /><searchLink fieldCode="AU" term="%22de+Aragão+Tavares+E%22">de Aragão Tavares E</searchLink>; Health Sciences Center, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, Natal, Brazil; Research Group of Bioactive Natural Products, Health Sciences Center, Pharmacy Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Electronic address: emanuella_ta@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Pinheiro+FASD%22">Pinheiro FASD</searchLink>; Health Sciences Center, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, Natal, Brazil. Electronic address: ayrtonsennap@gmail.com.<br /><searchLink fieldCode="AU" term="%22De+Santis+Ferreira+L%22">De Santis Ferreira L</searchLink>; Health Sciences Center, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, Natal, Brazil. Electronic address: leandro.ferreira@ufrn.br.<br /><searchLink fieldCode="AU" term="%22Zanatta+AC%22">Zanatta AC</searchLink>; Faculty of Pharmaceutical Science of Ribeirão Preto, University of São Paulo, USP, Ribeirão Preto, São Paulo, Brazil. Electronic address: anaczanatta@gmail.com.<br /><searchLink fieldCode="AU" term="%22de+Moura+DR%22">de Moura DR</searchLink>; Faculty of Pharmaceutical Science of Ribeirão Preto, University of São Paulo, USP, Ribeirão Preto, São Paulo, Brazil. Electronic address: diegomoura@usp.br.<br /><searchLink fieldCode="AU" term="%22de+Araujo+AA%22">de Araujo AA</searchLink>; Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil. Electronic address: aurigena.antunes@ufrn.br.<br /><searchLink fieldCode="AU" term="%22de+Araújo+Júnior+RF%22">de Araújo Júnior RF</searchLink>; Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil. Electronic address: fernandes.araujo@ufrn.br.<br /><searchLink fieldCode="AU" term="%22Guerra+GCB%22">Guerra GCB</searchLink>; Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil; Postgraduate Program in Biochemistry and Molecular Biology, Biosciences Center, Federal University of Rio Grande Norte, Natal, Brazil. Electronic address: gerlane.guerra@ufrn.br.<br /><searchLink fieldCode="AU" term="%22Zucolotto+SM%22">Zucolotto SM</searchLink>; Health Sciences Center, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, Natal, Brazil; Research Group of Bioactive Natural Products, Health Sciences Center, Pharmacy Department, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil; Postgraduate Program in Development and Technological Innovation in Medicines, Health Sciences Center, Natal, Rio Grande do Norte, Brazil. Electronic address: silvana.zucolotto@ufrn.br.
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  Data: <searchLink fieldCode="JN" term="%227903310%22">Journal of ethnopharmacology</searchLink> [J Ethnopharmacol] 2026 Oct 28; Vol. 369, pp. 121818. <i>Date of Electronic Publication: </i>2026 May 14.
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