Naïve CD4+ T-cells and disease status at CART infusion correlate with clinical outcomes in real-world large B-cell lymphoma patients receiving second-line CAR T therapy.

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Title: Naïve CD4+ T-cells and disease status at CART infusion correlate with clinical outcomes in real-world large B-cell lymphoma patients receiving second-line CAR T therapy.
Authors: Schneider M; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Paruzzo L; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA., Stella F; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; University of Milan, Milan, Italy., Noll JH; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA., Ho M; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA., Babatunde V; Division of Nuclear Medicine Imaging and Therapy, Hospital of the University of Pennsylvania, Philadelphia, PA, USA., Ho B; Division of Nuclear Medicine Imaging and Therapy, Hospital of the University of Pennsylvania, Philadelphia, PA, USA., Devi P; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA., Chong EA; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Barta SK; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Nasta SD; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Svoboda J; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Carter J; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Cook MR; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Hossain NM; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Thomas CJ; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Patel V; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA., de Souza VB; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA., Alkhatib MH; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA., Li Z; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA., Tan M; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA., Michener P; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA., Guruprasad P; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA., Imparato A; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Carturan A; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA., Porazzi P; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA., Fraietta JA; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Philadelphia, PA, USA., Schuster SJ; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Maillard I; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Division of Hematologic Malignancies & Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ruella M; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu., Landsburg DJ; Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. daniel.landsburg@pennmedicine.upenn.edu.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA. daniel.landsburg@pennmedicine.upenn.edu.; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. daniel.landsburg@pennmedicine.upenn.edu.
Source: Nature communications [Nat Commun] 2026 May 15; Vol. 17 (1). Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-71710-7