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Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease.

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Title: Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease.
Authors: Lu L; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden. lina.lu@med.lu.se., Pichet Binette A; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.; Department of Physiology and Pharmacology, Université de Montréal, Montréal, Quebec, Canada.; Centre de recherche de l'institut universitaire de gériatrie de Montréal (CRIUGM), Montréal, Quebec, Canada., Hristovska I; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden., Janelidze S; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden., Smets B; Johnson & Johnson, Beerse, Belgium., Cumplido-Mayoral I; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden., Vasanthakumar A; AbbVie, North Chicago, IL, USA., Milkovich B; AbbVie, North Chicago, IL, USA., An L; Department of Clinical Sciences Malmö, SciLifeLab, Lund University, Lund, Sweden., Ossenkoppele R; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.; Amsterdam Neuroscience, Neurodegeneration, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands., Krish V; Gates Ventures, Seattle, WA, USA., Imam F; Gates Ventures, Seattle, WA, USA., Palmqvist S; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Vogel JW; Department of Clinical Sciences Malmö, SciLifeLab, Lund University, Lund, Sweden., Stomrud E; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden., Mattsson-Carlgren N; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden. niklas.mattsson-carlgren@med.lu.se.; Memory Clinic, Skåne University Hospital, Malmö, Sweden. niklas.mattsson-carlgren@med.lu.se.
Corporate Authors: Global Neurodegeneration Proteomics Consortium (GNPC)
Source: Nature aging [Nat Aging] 2026 May; Vol. 6 (5), pp. 1138-1157. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lu+L%22">Lu L</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden. lina.lu@med.lu.se.<br /><searchLink fieldCode="AU" term="%22Pichet+Binette+A%22">Pichet Binette A</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.; Department of Physiology and Pharmacology, Université de Montréal, Montréal, Quebec, Canada.; Centre de recherche de l'institut universitaire de gériatrie de Montréal (CRIUGM), Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Hristovska+I%22">Hristovska I</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Janelidze+S%22">Janelidze S</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Smets+B%22">Smets B</searchLink>; Johnson & Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Cumplido-Mayoral+I%22">Cumplido-Mayoral I</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Vasanthakumar+A%22">Vasanthakumar A</searchLink>; AbbVie, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Milkovich+B%22">Milkovich B</searchLink>; AbbVie, North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22An+L%22">An L</searchLink>; Department of Clinical Sciences Malmö, SciLifeLab, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Ossenkoppele+R%22">Ossenkoppele R</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.; Amsterdam Neuroscience, Neurodegeneration, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Krish+V%22">Krish V</searchLink>; Gates Ventures, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Imam+F%22">Imam F</searchLink>; Gates Ventures, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Palmqvist+S%22">Palmqvist S</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Vogel+JW%22">Vogel JW</searchLink>; Department of Clinical Sciences Malmö, SciLifeLab, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Stomrud+E%22">Stomrud E</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Hansson+O%22">Hansson O</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Mattsson-Carlgren+N%22">Mattsson-Carlgren N</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden. niklas.mattsson-carlgren@med.lu.se.; Memory Clinic, Skåne University Hospital, Malmö, Sweden. niklas.mattsson-carlgren@med.lu.se.
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2026 May; Vol. 6 (5), pp. 1138-1157. <i>Date of Electronic Publication: </i>2026 May 15.
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