Population-scale genomic medicine with the Hong Kong Genome Project.

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Title: Population-scale genomic medicine with the Hong Kong Genome Project.
Authors: Ying D; Hong Kong Genome Institute, Hong Kong SAR, China., Cheung CL; Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Laboratory of Data Discovery for Health Limited (D24H), Hong Kong Science Parks, Hong Kong SAR, China.; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA., O CK; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Lam WKJ; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.; Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China., Au Yeung SL; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Lau CS; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Luk HM; Department of Clinical Genetics, Hong Kong Children's Hospital, Hong Kong SAR, China., Leung CKS; Department of Ophthalmology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Department of Ophthalmology, Queen Mary Hospital, Hong Kong SAR, China.; Hong Kong Eye Hospital, Hong Kong SAR, China.; Grantham Hospital, Hong Kong SAR, China., Tse DMS; Hong Kong Genome Institute, Hong Kong SAR, China., Liu JSC; Hong Kong Genome Institute, Hong Kong SAR, China., Hue SPY; Hong Kong Genome Institute, Hong Kong SAR, China., Kwok JSL; Hong Kong Genome Institute, Hong Kong SAR, China., Yeung DLH; Hong Kong Genome Institute, Hong Kong SAR, China., Preusch CB; Hong Kong Genome Institute, Hong Kong SAR, China., Ma W; Hong Kong Genome Institute, Hong Kong SAR, China., Tang W; Hong Kong Genome Institute, Hong Kong SAR, China., Tong AHY; Hong Kong Genome Institute, Hong Kong SAR, China., Au LWC; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China., Chan JC; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China., Chan YH; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Cheng SSW; Department of Clinical Genetics, Hong Kong Children's Hospital, Hong Kong SAR, China., Chong SC; Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China.; Joint Baylor-CUHK Center of Medical Genetics, The Chinese University of Hong Kong, Hong Kong SAR, China., Fung CW; Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong SAR, China., Ho S; Department of Clinical Genetics, Hong Kong Children's Hospital, Hong Kong SAR, China., Krishnamoorthy S; Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Leung GM; Laboratory of Data Discovery for Health Limited (D24H), Hong Kong Science Parks, Hong Kong SAR, China.; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Li PH; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Li Q; Department of Ophthalmology, Queen Mary Hospital, Hong Kong SAR, China.; Grantham Hospital, Hong Kong SAR, China., Loong HH; Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.; State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China., Lui RNS; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.; Medical Data Analytics Centre, The Chinese University of Hong Kong, Hong Kong SAR, China.; Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China., Luo S; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Ma BM; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Ma RCW; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China., Na R; Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Tan KCB; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Wong SS; Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong SAR, China., Lo SV; Hong Kong Genome Institute, Hong Kong SAR, China., Chu ATW; Hong Kong Genome Institute, Hong Kong SAR, China., Chung BHY; Hong Kong Genome Institute, Hong Kong SAR, China. bhychung@hku.hk.; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. bhychung@hku.hk.
Corporate Authors: Hong Kong Genome Project
Source: Nature medicine [Nat Med] 2026 Jun; Vol. 32 (6), pp. 2277-2287. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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Hong Kong Genome Institute, Hong Kong SAR, China. bhychung@hku.hk.; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. bhychung@hku.hk.
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