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Protein-based pan-RAS inhibitor induces tumor regression in female mice via IFNγ and CD8+ T cell-dependent tumor necrosis.

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Title: Protein-based pan-RAS inhibitor induces tumor regression in female mice via IFNγ and CD8+ T cell-dependent tumor necrosis.
Authors: Nomura TK; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan., Heishima K; Center for One Medicine Innovative Translational Research (COMIT), Gifu University, Gifu, Japan.; Institute for Advanced Study, Gifu University, Gifu, Japan., Mukai H; Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan., Arai K; Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan., Elhelaly AE; Department of Radiology, Gifu University, Gifu, Japan.; Department of Frontier Science for Imaging, School of Medicine, Gifu University, Gifu, Japan.; Department of Food Hygiene and Control, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt., Fuchigami H; Division of Developmental Therapeutics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan., Warashina S; Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan., Tahara T; Department of In vivo Imaging, Advanced Research Promoting Center, Tokushima University, Tokushima, Japan., Hyodo F; Center for One Medicine Innovative Translational Research (COMIT), Gifu University, Gifu, Japan.; Innovation Research Center for Quantum Medicine, Gifu University, Gifu, Japan.; Department of Pharmacology, School of Medicine, Gifu University, Gifu, Japan., Matsuo M; Department of Radiology, Gifu University, Gifu, Japan.; Innovation Research Center for Quantum Medicine, Gifu University, Gifu, Japan., Yasunaga M; Division of Developmental Therapeutics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan., Aoki K; Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan., Honda R; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan. ryohonda.rh@gmail.com.; Center for One Medicine Innovative Translational Research (COMIT), Gifu University, Gifu, Japan. ryohonda.rh@gmail.com.; Innovation Research Center for Quantum Medicine, Gifu University, Gifu, Japan. ryohonda.rh@gmail.com.
Source: Nature communications [Nat Commun] 2026 May 16; Vol. 17 (1). Date of Electronic Publication: 2026 May 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Protein-based pan-RAS inhibitor induces tumor regression in female mice via IFNγ and CD8<superscript>+</superscript> T cell-dependent tumor necrosis.
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  Data: <searchLink fieldCode="AU" term="%22Nomura+TK%22">Nomura TK</searchLink>; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.<br /><searchLink fieldCode="AU" term="%22Heishima+K%22">Heishima K</searchLink>; Center for One Medicine Innovative Translational Research (COMIT), Gifu University, Gifu, Japan.; Institute for Advanced Study, Gifu University, Gifu, Japan.<br /><searchLink fieldCode="AU" term="%22Mukai+H%22">Mukai H</searchLink>; Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Arai+K%22">Arai K</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Elhelaly+AE%22">Elhelaly AE</searchLink>; Department of Radiology, Gifu University, Gifu, Japan.; Department of Frontier Science for Imaging, School of Medicine, Gifu University, Gifu, Japan.; Department of Food Hygiene and Control, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.<br /><searchLink fieldCode="AU" term="%22Fuchigami+H%22">Fuchigami H</searchLink>; Division of Developmental Therapeutics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Warashina+S%22">Warashina S</searchLink>; Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Tahara+T%22">Tahara T</searchLink>; Department of In vivo Imaging, Advanced Research Promoting Center, Tokushima University, Tokushima, Japan.<br /><searchLink fieldCode="AU" term="%22Hyodo+F%22">Hyodo F</searchLink>; Center for One Medicine Innovative Translational Research (COMIT), Gifu University, Gifu, Japan.; Innovation Research Center for Quantum Medicine, Gifu University, Gifu, Japan.; Department of Pharmacology, School of Medicine, Gifu University, Gifu, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuo+M%22">Matsuo M</searchLink>; Department of Radiology, Gifu University, Gifu, Japan.; Innovation Research Center for Quantum Medicine, Gifu University, Gifu, Japan.<br /><searchLink fieldCode="AU" term="%22Yasunaga+M%22">Yasunaga M</searchLink>; Division of Developmental Therapeutics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Aoki+K%22">Aoki K</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Honda+R%22">Honda R</searchLink>; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan. ryohonda.rh@gmail.com.; Center for One Medicine Innovative Translational Research (COMIT), Gifu University, Gifu, Japan. ryohonda.rh@gmail.com.; Innovation Research Center for Quantum Medicine, Gifu University, Gifu, Japan. ryohonda.rh@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 May 16; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 16.
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