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Tie2 inhibition disrupts TMEM doorway function and reduces dissemination in pancreatic ductal adenocarcinoma.

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Title: Tie2 inhibition disrupts TMEM doorway function and reduces dissemination in pancreatic ductal adenocarcinoma.
Authors: Zambalde EP; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA., Ariyan LA; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA., Puerta-Martinez F; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA., Zhu YQ; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA., Patil P; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, New York, NY, USA., Panarelli NC; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Li J; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA., Jung Y; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Gruss-Lipper Biphotonic Center, Albert Einstein College of Medicine, New York, NY, USA., Adkisson C; Department of Surgery, Albert Einstein College of Medicine, New York, NY, USA., Petersen J; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA., Cox D; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA., Gil-Henn H; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA., Eddy R; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA., Stanger BZ; Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104-5157, USA., Entenberg D; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.; Gruss-Lipper Biphotonic Center, Albert Einstein College of Medicine, New York, NY, USA., Oktay MH; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, New York, NY, USA.; Cancer Dormancy and Tumor Microenvironment Institute, Albert Einstein College of Medicine, New York, NY, USA., Condeelis JS; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, New York, NY, USA.; Cancer Dormancy and Tumor Microenvironment Institute, Albert Einstein College of Medicine, New York, NY, USA.; Gruss-Lipper Biphotonic Center, Albert Einstein College of Medicine, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.; Department of Surgery, Albert Einstein College of Medicine, New York, NY, USA., McAuliffe JC; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA. jomcauli@montefiore.org.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA. jomcauli@montefiore.org.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, New York, NY, USA. jomcauli@montefiore.org.; Department of Surgery, Albert Einstein College of Medicine, New York, NY, USA. jomcauli@montefiore.org.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 May 16; Vol. 45 (1). Date of Electronic Publication: 2026 May 16.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tie2 inhibition disrupts TMEM doorway function and reduces dissemination in pancreatic ductal adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Zambalde+EP%22">Zambalde EP</searchLink>; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ariyan+LA%22">Ariyan LA</searchLink>; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Puerta-Martinez+F%22">Puerta-Martinez F</searchLink>; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+YQ%22">Zhu YQ</searchLink>; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Patil+P%22">Patil P</searchLink>; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Panarelli+NC%22">Panarelli NC</searchLink>; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Jung+Y%22">Jung Y</searchLink>; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Gruss-Lipper Biphotonic Center, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Adkisson+C%22">Adkisson C</searchLink>; Department of Surgery, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Petersen+J%22">Petersen J</searchLink>; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cox+D%22">Cox D</searchLink>; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gil-Henn+H%22">Gil-Henn H</searchLink>; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Eddy+R%22">Eddy R</searchLink>; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Stanger+BZ%22">Stanger BZ</searchLink>; Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104-5157, USA.<br /><searchLink fieldCode="AU" term="%22Entenberg+D%22">Entenberg D</searchLink>; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.; Gruss-Lipper Biphotonic Center, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Oktay+MH%22">Oktay MH</searchLink>; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, New York, NY, USA.; Cancer Dormancy and Tumor Microenvironment Institute, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Condeelis+JS%22">Condeelis JS</searchLink>; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, New York, NY, USA.; Cancer Dormancy and Tumor Microenvironment Institute, Albert Einstein College of Medicine, New York, NY, USA.; Gruss-Lipper Biphotonic Center, Albert Einstein College of Medicine, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.; Department of Surgery, Albert Einstein College of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22McAuliffe+JC%22">McAuliffe JC</searchLink>; Department of Pathology, Albert Einstein College of Medicine, New York, NY, USA. jomcauli@montefiore.org.; Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine, New York, NY, USA. jomcauli@montefiore.org.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, New York, NY, USA. jomcauli@montefiore.org.; Department of Surgery, Albert Einstein College of Medicine, New York, NY, USA. jomcauli@montefiore.org.
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